COMPARISON OF BIODISTRIBUTION OF ¹¹¹IN-TROPOLONE LEUKOCYTES AND 125 I-HUMAN NONSPECIFIC POLYCLONAL IGG IN NORMAL AND INDUCED INFLAMMATION MICE FOR DETECTION OF INFLAMMATION

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SHAHHOSSEINI S.; HADIZAD T.; BABAEI M.H.; NAJAFI R.

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Journal Paper

Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2001 | Volume:9 | Issue:3-4 Page(s): 9-17

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Title

COMPARISON OF BIODISTRIBUTION OF ¹¹¹IN-TROPOLONE LEUKOCYTES AND 125 I-HUMAN NONSPECIFIC POLYCLONAL IGG IN NORMAL AND INDUCED INFLAMMATION MICE FOR DETECTION OF INFLAMMATION

Author(s)

SHAHHOSSEINI S. | HADIZAD T. | BABAEI M.H. | NAJAFI R. | Issue Writer Certificate

Keywords

IMMUNOSCINTIGRAPHY

ACID CITRATE DEXTROSE (ACD)

HYDROXY ETHYL STARCH (HES)

TURPENTINE

IMMUNOGLOBULIN (IG)

PERCENT INJECTED DOSE PER GRAM TISSUE (%ID/G)

Abstract

Human nonspecific polyclonal IgG and granulocytes, which accumulate in inflammation foci, were radiolabeled with 125I and ¹¹¹In-Tropolone, respectively. Biodistribution of these two radiolabels was assessed in normal and inflammation-induced mice. 125I-IgG showed better localization to the inflammated areas. Blood levels with ¹¹¹In-Tropolone leukocytes were lower at all time points. In addition, the inflammatory thigh-to-blood ratios showed an improvement, whereas the ratios of inflammatory thigh-to-other normal tissues were higher for 125I-IgG than ¹¹¹In-Tropolone leukocytes. In conclusion, labeled IgG due to better localization in inflammated sites and higher target-to-background ratios is more suitable agent than labeled leukocytes for IMMUNOSCINTIGRAPHY of inflammation.

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APA: Copy

SHAHHOSSEINI, S., HADIZAD, T., BABAEI, M.H., & NAJAFI, R.. (2001). COMPARISON OF BIODISTRIBUTION OF ¹¹¹IN-TROPOLONE LEUKOCYTES AND 125 I-HUMAN NONSPECIFIC POLYCLONAL IGG IN NORMAL AND INDUCED INFLAMMATION MICE FOR DETECTION OF INFLAMMATION. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 9(3-4), 9-17. SID. https://sid.ir/paper/275295/en

Vancouver: Copy

SHAHHOSSEINI S., HADIZAD T., BABAEI M.H., NAJAFI R.. COMPARISON OF BIODISTRIBUTION OF ¹¹¹IN-TROPOLONE LEUKOCYTES AND 125 I-HUMAN NONSPECIFIC POLYCLONAL IGG IN NORMAL AND INDUCED INFLAMMATION MICE FOR DETECTION OF INFLAMMATION. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2001;9(3-4):9-17. Available from: https://sid.ir/paper/275295/en

IEEE: Copy

S. SHAHHOSSEINI, T. HADIZAD, M.H. BABAEI, and R. NAJAFI, “COMPARISON OF BIODISTRIBUTION OF ¹¹¹IN-TROPOLONE LEUKOCYTES AND 125 I-HUMAN NONSPECIFIC POLYCLONAL IGG IN NORMAL AND INDUCED INFLAMMATION MICE FOR DETECTION OF INFLAMMATION,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 9, no. 3-4, pp. 9–17, 2001, [Online]. Available: https://sid.ir/paper/275295/en

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