DETERMINATION OF MYCOPHENOLIC ACID IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

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AHADI BARZOKI M.; ROUINI M.R.; GHOLAMI KH.A.; LESANPEZESHKI M.; REZAEI SAEID

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Journal Paper

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Journal: DARU Journal of Pharmaceutical Sciences Year:2005 | Volume:13 | Issue:3 Page(s): 120-126

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Title

DETERMINATION OF MYCOPHENOLIC ACID IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

Author(s)

Keywords

MYCOPHENOLIC ACID

MYCOPHENOLATE MOFETILE

HPLC

PLASMA

KIDNEY TRANSPLANT

Abstract

A simple, sensitive and reproducible HPLC method is presented for determination of MYCOPHENOLIC ACID (MPA) in human PLASMA. Samples were prepared after precipitation of the PLASMA protein by addition of acetonitrile and naproxen was used as internal standard (I.S.). Separation was performed by reversed phase HPLC, using a Hamilton PRP-C18 Column, 51% acetonitrile and 49% potassium phosphate buffer (20 mM) at pH 3.0 as mobile phase, flow rate of 1.0 ml/min, and UV detection at 215 nm. MPA and I.S. had retention times of 7.5 and 11.35 min, respectively. The method showed an acceptable linearity in the range of 0.1µg/ml-40µg/ml with r2 of .9992. The concentration of 0.1µg/ml was determined as quantification limit. Mean absolute recovery was 94.8%. The mean intra- and inter-day reproducibility of method was 4.6 and 11.4% respectively.

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APA: Copy

AHADI BARZOKI, M., ROUINI, M.R., GHOLAMI, KH.A., LESANPEZESHKI, M., & REZAEI, SAEID. (2005). DETERMINATION OF MYCOPHENOLIC ACID IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 13(3), 120-126. SID. https://sid.ir/paper/275308/en

Vancouver: Copy

AHADI BARZOKI M., ROUINI M.R., GHOLAMI KH.A., LESANPEZESHKI M., REZAEI SAEID. DETERMINATION OF MYCOPHENOLIC ACID IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2005;13(3):120-126. Available from: https://sid.ir/paper/275308/en

IEEE: Copy

M. AHADI BARZOKI, M.R. ROUINI, KH.A. GHOLAMI, M. LESANPEZESHKI, and SAEID REZAEI, “DETERMINATION OF MYCOPHENOLIC ACID IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 13, no. 3, pp. 120–126, 2005, [Online]. Available: https://sid.ir/paper/275308/en

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