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Information Journal Paper

Title

INFLUENCE OF DIFFERENT SUGAR CRYOPROTECTANTS ON THE STABILITY AND PHYSICO-CHEMICAL CHARACTERISTICS OF FREEZE-DRIED 5-FLUOROURACIL PLURILAMELLAR VESICLES

Pages

  133-142

Abstract

 Lyophilization increases the shelf-life of liposomes by preserving it in a dry form as lyophilized cake to be reconstituted with water immediately prior to administration. Aiming at increasing stability and availability of 5-FLUOROURACIL liposomal products, 5-Fluorouacil STABLE PLURILAMELLAR VESICLES were prepared. Freeze dried liposomal dispersions were prepared with or without CRYOPROTECTANTS. The CRYOPROTECTANTS used were glucose, mannitol or TREHALOSE in 1, 2 and 4 grams per gram phospholipids. The results showed that lyophilized cake of liposomes without CRYOPROTECTANTS was compact and difficult to reconstitute, in comparison with fluffy cakes which reconstituted easily and quickly when using CRYOPROTECTANTS. The percentage of 5-FLUOROURACIL retained in liposomes freeze-dried without CRYOPROTECTANTS was 18.29% ± 0.96% and the percentage of 5-FLUOROURACIL retained in STABLE PLURILAMELLAR VESICLES was 31.22% ± 0.62% using 4 grams TREHALOSE as cryoprotectant per gram of lipid. Physico-chemical and RELEASE STABILITY studies showed superior potentials of the lyophilized product after reconstitution in comparison to dispersion product. It may be concluded that all tested sugars have cryoprotectant effects that stabilized liposomes in the freeze dried state, where TREHALOSE offered the most superior cryoprotectant effect for freeze dried 5-FLUOROURACIL liposomes.

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    Cite

    APA: Copy

    NOUNOU, M.M., EL-KHORDAGUI, L., KHALAFALLAH, N., KHALIL, S., & RASHEED, K.. (2005). INFLUENCE OF DIFFERENT SUGAR CRYOPROTECTANTS ON THE STABILITY AND PHYSICO-CHEMICAL CHARACTERISTICS OF FREEZE-DRIED 5-FLUOROURACIL PLURILAMELLAR VESICLES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 13(4), 133-142. SID. https://sid.ir/paper/275314/en

    Vancouver: Copy

    NOUNOU M.M., EL-KHORDAGUI L., KHALAFALLAH N., KHALIL S., RASHEED K.. INFLUENCE OF DIFFERENT SUGAR CRYOPROTECTANTS ON THE STABILITY AND PHYSICO-CHEMICAL CHARACTERISTICS OF FREEZE-DRIED 5-FLUOROURACIL PLURILAMELLAR VESICLES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2005;13(4):133-142. Available from: https://sid.ir/paper/275314/en

    IEEE: Copy

    M.M. NOUNOU, L. EL-KHORDAGUI, N. KHALAFALLAH, S. KHALIL, and K. RASHEED, “INFLUENCE OF DIFFERENT SUGAR CRYOPROTECTANTS ON THE STABILITY AND PHYSICO-CHEMICAL CHARACTERISTICS OF FREEZE-DRIED 5-FLUOROURACIL PLURILAMELLAR VESICLES,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 13, no. 4, pp. 133–142, 2005, [Online]. Available: https://sid.ir/paper/275314/en

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