مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

364
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

155
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

LEAD EXPOSURE IMPAIRS NMDA AGONIST-INDUCED NO PRODUCTION IN PYRAMIDAL HIPPOCAMPAL CELLS

Pages

  44-50

Abstract

 Chronic exposure to Lead (Pb) affects neural functions in central nervous system (CNS) particularly the learning and memory. On the other hand, alteration of calcium level in the CNS results in activation of NOS where it is expected to increase NITRIC OXIDE level in hippocampus. In this study the role of Lead exposure in NMDA induced NO production in pyramidal hippocampal cells (CA1HP) was investigated. The NO level was determined by measurement of concentration of nitrite and nitrate as NO products using the metHb production at 401 nm. The ACBD (NMDA agonist)-induced NO level was almost reduced to the control level (2.5 nM) in the presence of 10 and 100 nM of Lead acetate. LEAD ACETATE at concentrations which normally results in chronic toxicity did not increase the NITRIC OXIDE (NO) production by CA1HP. One reason for this finding could be the interaction of Lead with NMDA receptors due to similarity of Pb2+ to Zn2+ ion. Another reason may be related to direct interaction of Lead with NMDA receptors that inhibit the stimulated NO production.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    OSTAD, S.N., SHARIFZADEH, M., AZIZI, E.,. (2006). LEAD EXPOSURE IMPAIRS NMDA AGONIST-INDUCED NO PRODUCTION IN PYRAMIDAL HIPPOCAMPAL CELLS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 14(1), 44-50. SID. https://sid.ir/paper/275326/en

    Vancouver: Copy

    OSTAD S.N., SHARIFZADEH M., AZIZI E.. LEAD EXPOSURE IMPAIRS NMDA AGONIST-INDUCED NO PRODUCTION IN PYRAMIDAL HIPPOCAMPAL CELLS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2006;14(1):44-50. Available from: https://sid.ir/paper/275326/en

    IEEE: Copy

    S.N. OSTAD, M. SHARIFZADEH, E. AZIZI, an, “LEAD EXPOSURE IMPAIRS NMDA AGONIST-INDUCED NO PRODUCTION IN PYRAMIDAL HIPPOCAMPAL CELLS,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 14, no. 1, pp. 44–50, 2006, [Online]. Available: https://sid.ir/paper/275326/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button