PREPARATION AND IN VITRO ASSESSMENT OF VARIOUS MUCOSA-ADHESIVE FILMS FOR BUCCAL DELIVERY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MORTAZAVI S.A.A.GH.; ABOU FAZELI R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2000 | Volume:8 | Issue:1-2 Page(s): 9-18

Download Full-Text

View:

345

Download:

Cites:

Information Journal Paper

Title

PREPARATION AND IN VITRO ASSESSMENT OF VARIOUS MUCOSA-ADHESIVE FILMS FOR BUCCAL DELIVERY

Author(s)

MORTAZAVI S.A.A.GH. | ABOU FAZELI R. | Issue Writer Certificate

Keywords

BUCCAL FILMS

PATCHES

CARBOPOL 934P

MUCOADHESION

SODIUM CARBOXYMETHYL CELLULOSE

Abstract

The aim of this study was to examine various polymers considered to have mucosa-adhesive properties for the preparation of buccal-adhesive films and their in vitro evaluation. A number of materials, such as cellulose derivatives, carbopols and natural polymers, were employed for the preparation of buccal-adhesive films. Aqueous solutions containing the mucosa-adhesive polymer and a plasticizer were prepared and used to prepare films by the "solvent cast" method. Prepared filmswere then evaluated in terms of their physical appearance and film forming ability, in vitro mucosa-adhesive strength and duration of mucosa-adhesion.Results showed that among the various materials examined, SODIUM CARBOXYMETHYL CELLULOSE (CMC) formed very fle ible films with the greatest mucosa-adhesive strength. Further studies showed that the combination of carbopols and CMC, along with glycerin as the plasticizer, resulted in the formation of films with desirable appearance and a relatively stronger mucosa-adhesive strength than films containing CMC alone. In vitro studies showed that films containing CARBOPOL 934P, CMC and glycerin gave the greatest mucosa-adhesive strength and longer mucosa-adhesion. In conclusion, this formulation is proposed as a good base for the preparation of buccal-adhesive films and PATCHES. Furthermore, it is suggested that in the development of buccal-adhesive drug delivery systems, and in particular films and PATCHES, duration of mucosa-adhesion determined by in vitro experiments is a critical factor in the selection of the ultimate formulation.

Cites

References

Cite

APA: Copy

MORTAZAVI, S.A.A.GH., & ABOU FAZELI, R.. (2000). PREPARATION AND IN VITRO ASSESSMENT OF VARIOUS MUCOSA-ADHESIVE FILMS FOR BUCCAL DELIVERY. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 8(1-2), 9-18. SID. https://sid.ir/paper/275364/en

Vancouver: Copy

MORTAZAVI S.A.A.GH., ABOU FAZELI R.. PREPARATION AND IN VITRO ASSESSMENT OF VARIOUS MUCOSA-ADHESIVE FILMS FOR BUCCAL DELIVERY. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2000;8(1-2):9-18. Available from: https://sid.ir/paper/275364/en

IEEE: Copy

S.A.A.GH. MORTAZAVI, and R. ABOU FAZELI, “PREPARATION AND IN VITRO ASSESSMENT OF VARIOUS MUCOSA-ADHESIVE FILMS FOR BUCCAL DELIVERY,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 8, no. 1-2, pp. 9–18, 2000, [Online]. Available: https://sid.ir/paper/275364/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops