مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

408
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

198
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

DETERMINATION OF ISOSTEVIOL BY LC-MS/MS AND ITS APPLICATION FOR EVALUATION OF PHARMACOKINETICS OF ISOSTEVIOL IN RAT

Pages

  146-150

Abstract

 ISOSTEVIOL has been found to have potential preventive or therapeutic effects against hypertension, ischemia reperfusion injury, diabetes and cancer, but little is known about the PHARMACOKINETICS (PK) of the compound. The aim of this study was to develop a liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method for determination of ISOSTEVIOL in rat plasma and to assess in a preliminary manner the PK of ISOSTEVIOL after intravenous bolus injection. Ions of analytes were generated using electro-spray ionization and detected in the positive-ion mode in LC-MS/MS. Multiple reaction monitoring was performed, using the precursor product ion combination for ISOSTEVIOL m/z 319.4→273.4. Progesterone was used as an internal standard. Nitrogen was used as the nebulising gas and unit resolution was set for Q1 and Q3. ISOSTEVIOL solution was injected through the penile vein of RATS at a dose of 8 mg/kg. Blood samples were collected from a jugular vein cannula. The PK parameters were calculated using a two - compartment PK model. The LC-MS/MS assay for ISOSTEVIOL in rat plasma was linear over the range of 0.5-80 mg/ml. The terminal half life of ISOSTEVIOL (t 1/2) was 406±31.7 min and clearance (CL) was 2.9±0.3 ml/min/kg. A sensitive LC-MS/MS assay for ISOSTEVIOL in plasma has been successfully established and used in a preliminary PK evaluation of ISOSTEVIOL in RATS.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    BAZARGAN, M., GERBER, J.P., WANG, J., MILNE, R.W., EVANS, A.M., & CHITSAZ, MOHSEN. (2007). DETERMINATION OF ISOSTEVIOL BY LC-MS/MS AND ITS APPLICATION FOR EVALUATION OF PHARMACOKINETICS OF ISOSTEVIOL IN RAT. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 15(3), 146-150. SID. https://sid.ir/paper/275416/en

    Vancouver: Copy

    BAZARGAN M., GERBER J.P., WANG J., MILNE R.W., EVANS A.M., CHITSAZ MOHSEN. DETERMINATION OF ISOSTEVIOL BY LC-MS/MS AND ITS APPLICATION FOR EVALUATION OF PHARMACOKINETICS OF ISOSTEVIOL IN RAT. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2007;15(3):146-150. Available from: https://sid.ir/paper/275416/en

    IEEE: Copy

    M. BAZARGAN, J.P. GERBER, J. WANG, R.W. MILNE, A.M. EVANS, and MOHSEN CHITSAZ, “DETERMINATION OF ISOSTEVIOL BY LC-MS/MS AND ITS APPLICATION FOR EVALUATION OF PHARMACOKINETICS OF ISOSTEVIOL IN RAT,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 15, no. 3, pp. 146–150, 2007, [Online]. Available: https://sid.ir/paper/275416/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button