مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

415
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

231
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

ASSESSMENT OF ANTI-INFLAMMATORY PROPERTIES OF ETHYL ACETATE EXTRACT OF STACHYS SCHTSCHEGLEEVII SOSN

Pages

  174-182

Abstract

 Background: STACHYS SCHTSCHEGLEEVII Sosn. (commonly known as “Poulk” and “Sonbeleh Arasbarani”) and Stachys inflate Benth. (“Sonbeleh Arghavani”) are most widely used for medicinal purposes. STACHYS SCHTSCHEGLEEVII Sosn.( Lamiaceae) is widespread in North West of Iran and have been used traditionally to treat infections, asthma, rheumatic and other inflammatory disorders. In the present studies the ANTI-INFLAMMATORY activity of hydro-alcoholic extracts of both flowering and sterile tops of S. schtschegleevii were investigated. Material and Methods: The methanolic extract of the sterile aerial parts was partitionated between chloroform, ethyl acetate and n-butanol. The column chromatography (CC) on silica gel was used to fractionate the ethyl acetate extract and the ANTI-INFLAMMATORY effects of each main fraction were evaluated by CARRAGEENAN-INDUCED RAT PAW OEDEMA ASSAY. The reversed-phase preparative HPLC was used to isolate compounds from the active fractions and their structure (1-3) were elucidated by spectroscopic means. The ethyl acetate portion was fractionated into 11 major fractions. Results: the most prominent ANTI-INFLAMMATORY effect was observed with fractions 8 to 10 of the ethyl acetate portion. Fraction 8 abolished considerably the mean maximal responses of inflammation from 87.00±3.5% in control to 61.10±7.2% (p<0.001) and 62.10±3.6% (p<0.001) in 15 and 30 mg/kg fraction-treated groups, respectively. Preparative-HPLC analyses of fractions 5 and 8-10 led to the isolation and identification of three major compounds, chrysoeriol 7-O-b-[6”-(p- coumaroyl)]-glucoside (1), apigenin 7-O-b-[6”-(p- coumaroyl)]-glucoside (2), and ACTEOSIDE (3). Conclusion: It seems that CAFFEIC ACID DERIVATIVES such as ACTEOSIDE may be implicated in ANTI-INFLAMMATORY effect of Stachys schetschegleevii Sosn.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    NAZEMIEH, H., MALEKI, N., MEHMANI, F., GARJANI, A., KUMARASAMY, Y., & SARKER, S.D.. (2007). ASSESSMENT OF ANTI-INFLAMMATORY PROPERTIES OF ETHYL ACETATE EXTRACT OF STACHYS SCHTSCHEGLEEVII SOSN. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 15(4), 174-182. SID. https://sid.ir/paper/275422/en

    Vancouver: Copy

    NAZEMIEH H., MALEKI N., MEHMANI F., GARJANI A., KUMARASAMY Y., SARKER S.D.. ASSESSMENT OF ANTI-INFLAMMATORY PROPERTIES OF ETHYL ACETATE EXTRACT OF STACHYS SCHTSCHEGLEEVII SOSN. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2007;15(4):174-182. Available from: https://sid.ir/paper/275422/en

    IEEE: Copy

    H. NAZEMIEH, N. MALEKI, F. MEHMANI, A. GARJANI, Y. KUMARASAMY, and S.D. SARKER, “ASSESSMENT OF ANTI-INFLAMMATORY PROPERTIES OF ETHYL ACETATE EXTRACT OF STACHYS SCHTSCHEGLEEVII SOSN,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 15, no. 4, pp. 174–182, 2007, [Online]. Available: https://sid.ir/paper/275422/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button