THE EFFECT OF ENALAPRIL ON INFLAMMATION AND IL-1BETA AND IL-8 PRODUCTION IN CHRONIC ARTHRITIS

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NIKBAKHT F.; NAJAFIPOUR H.; DABIRI SH.

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Journal: DARU Journal of Pharmaceutical Sciences Year:2007 | Volume:15 | Issue:4 Page(s): 193-198

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Information Journal Paper

Title

THE EFFECT OF ENALAPRIL ON INFLAMMATION AND IL-1BETA AND IL-8 PRODUCTION IN CHRONIC ARTHRITIS

Author(s)

NIKBAKHT F. | NAJAFIPOUR H. | DABIRI SH. | Issue Writer Certificate

Keywords

ENALAPRIL

CHRONIC ARTHRITIS

CYTOKINES

ACE INHIBITORS

Abstract

Background and the purpose of the study: Angiotensin II (Ang II) other than acting as a vasopressor hormone has pro-inflammatory properties. Since angiotensin-converting enzyme (ACE), is present in inflamed synovial membrane, in this study the effect of ENALAPRIL in modulation of inflammation and cytokine production in experimental induced CHRONIC ARTHRITIS was investigated. Methods: Chronic joint inflammation was induced by antigen-induced arthritis method in rabbits and ENALAPRIL was given orally (7.5mg/kg/day) two weeks before (prophylaxis group) or two weeks after (treatment group) induction. Serum of arthritis's ACE activity was measured by HPLC, pro-inflammatory CYTOKINES, IL-1b & IL-8 were measured in synovial fluid, and histology of knee joints was assessed in both groups. Results: Results revealed that ENALAPRIL reduced ACE activity in serum significantly (P=0.004), had no effect on IL-8 of synovial fluid and reduced the IL-1b production (P<0.05). Histological results revealed a significant reduction in villous hyperplasia and pannus formation (P<0.05 in both groups). While in prophylaxis group no bone erosion was observed and the cartilage was either intact or slightly invaded by synoviocytes, in non-treated group the cartilage was mostly invaded. Conclusion: ENALAPRIL reduces production of pro-inflammatory cytokine IL-1b and severity of joint damage in CHRONIC ARTHRITIS and may have therapeutics benefits in inflammatory joint diseases.

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APA: Copy

NIKBAKHT, F., NAJAFIPOUR, H., & DABIRI, SH.. (2007). THE EFFECT OF ENALAPRIL ON INFLAMMATION AND IL-1BETA AND IL-8 PRODUCTION IN CHRONIC ARTHRITIS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 15(4), 193-198. SID. https://sid.ir/paper/275426/en

Vancouver: Copy

NIKBAKHT F., NAJAFIPOUR H., DABIRI SH.. THE EFFECT OF ENALAPRIL ON INFLAMMATION AND IL-1BETA AND IL-8 PRODUCTION IN CHRONIC ARTHRITIS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2007;15(4):193-198. Available from: https://sid.ir/paper/275426/en

IEEE: Copy

F. NIKBAKHT, H. NAJAFIPOUR, and SH. DABIRI, “THE EFFECT OF ENALAPRIL ON INFLAMMATION AND IL-1BETA AND IL-8 PRODUCTION IN CHRONIC ARTHRITIS,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 15, no. 4, pp. 193–198, 2007, [Online]. Available: https://sid.ir/paper/275426/en

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