@CORONARY ARTERY DISEASE IS ASSOCIATED WITH THE RATIO OF APOLIPOPROTEINA-I/B AND SERUM CONCENTRATION OF APOLIPOPROTEIN B, BUT NOT WITH PARAOXONASE ENZYME ACTIVITY IN IRANIAN SUBJECTS

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RAHMANI M.; RAEISZADEH F.; ALLAH VERDIAN S.; MOTAMEDI M.R.; AZIZI F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2000 | Volume:2 | Issue:1 (SN 5) Page(s): 19-30

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Title

@CORONARY ARTERY DISEASE IS ASSOCIATED WITH THE RATIO OF APOLIPOPROTEINA-I/B AND SERUM CONCENTRATION OF APOLIPOPROTEIN B, BUT NOT WITH PARAOXONASE ENZYME ACTIVITY IN IRANIAN SUBJECTS

Author(s)

Keywords

APOLIPOPROTEINQ4

PARAOXONASEQ4

CORONARY ARTERY DISEASEQ3

LIPOPROTEINQ4

DIABETES MELLITUSQ2

Abstract

To determine the association of serum APOLIPOPROTEIN (apo) A-I and apo B concentrations, and PARAOXONASE (PON) high-density LIPOPROTEIN (HDL) associated enzyme activity with angiographically determined CORONARY ARTERY DISEASE (CAD) in Iranian diabetic and nondiabetic CAD patients and nondiabetic control subjects, 251 subjects aged 30-70 years, who underwent their first coronary angiography were matched and randomly assigned into three groups: CAD+DM+, CAD+DM-, and CAD-DM- (control). Stenosis of >= 50% in 1 or more coronary arteries was classified as CAD+. CAD- was defined as a maximum stenosis of 10% in any coronary artery. Fasting serum concentrations of cholesterol (TC), triglycerides (TGs), LDL-C, HDL-C, apo A-I, apo B, and PON activity were determined. APOLIPOPROTEIN concentrations were measured in a fasting serum sample by immunoturbidometric assay and PARAOXONASE/arylesterase activities by spectrophotometric assay of p-nitrophenol/phenol production following addition of paraoxon/phenylacetate. Information concerning nonlipid risk factors were collected by questionnaires. No significant difference was observed in HDL-C, LDL-C, apo A-I, and PON/arylesterase activity between the study groups. The values of TC (213±38 vs 196±45, p<0.05), TGs (209±187 vs 151±113, p<0.005), apo B (99±22 vs 96±24, p<0.0001), TC/HDL-C (4.8±1.5 vs 4.0±1.3, p<0.001), and LDL-C/HDL-C (2.9±1.1 vs 2.4±1.1, p<0.05) were higher and apo A-I / apo B (1.7±0.4 vs 2.0±0.6, p<0.01) was lower in CAD+DM+ patients than in control subjects. In CAD+DM- group, only the level of apo B (96±24 vs 85±18, p<0.01), and the ratio of apo A-I/apo B (1.8±0.4 vs 2.0±0.6, p<0.01), were significantly higher than those of control group. On multiple logistic regression analysis, the best markers for discrimination between CAD+ groups and CAD- control subjects were the ratio of apo A-I/apo B in diabetic and apo B in nondiabetic patients. The results suggest that in Iranian diabetic and nondiabetic patients with CAD the concentration of APOLIPOPROTEINs are better markers than traditional lipid parameters in discriminating between CAD+ and CAD- subjects. Lack of significant difference in PON activity between CAD+ patients and CAD- controls supports the concept of interethnic variability in PON polymorphism and unimodal distribution of its activity in non-Europid populations observed in other studies.

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