مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

345
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

107
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

COMPARISON OF MASS TRANSFER MODELS FOR DETERMINATION OF THE INTESTINAL PERMEABILITY

Pages

  203-210

Abstract

 Background and the purpose of the study: In determination of the PERMEABILITY of the intestinal wall by external PERFUSION techniques, several models have been proposed. In the present study three models were used for experimental results that differ in their convection and diffusion assumptions. Material and Methods: PERMEABILITY coefficients for 13 compounds (metoprolol, propranolol, naproxen, ketoprofen, furosemide, hydrochlorothiazide, cimetidine, ranitidine, atenolol, piroxicam, antipyrine, ibuprofen and carbamazepine) with known human intestinal PERMEABILITY values were determined in anaesthetized rats by different MASS TRANSFER models and plotted versus the observed human intestinal permeabilities. Results: The calculated dimensionless wall PERMEABILITY values were in the range of 0.37-4.85, 0.38-6.54 and 0.41-16.59 for complete radial mixing, mixing tank and LAMINAR FLOW models respectively. The results indicated that all of the models work relatively well for our data despite fundamentally different assumptions. The wall permeabilities were in the order LAMINAR FLOW>mixing tank>complete radial mixing. Conclusion: Although LAMINAR FLOW model provides the most direct measure of the intrinsic wall PERMEABILITY, it has limitations for highly permeable drugs such as ibuprofen. The normal physiological hydrodynamics is more complex and more investigation is required to find out the real hydrodynamics.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    VALIZADEH, H., TAJERZADEH, H., & ZAKERI MILANI, P.. (2008). COMPARISON OF MASS TRANSFER MODELS FOR DETERMINATION OF THE INTESTINAL PERMEABILITY. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 16(4), 203-210. SID. https://sid.ir/paper/275470/en

    Vancouver: Copy

    VALIZADEH H., TAJERZADEH H., ZAKERI MILANI P.. COMPARISON OF MASS TRANSFER MODELS FOR DETERMINATION OF THE INTESTINAL PERMEABILITY. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2008;16(4):203-210. Available from: https://sid.ir/paper/275470/en

    IEEE: Copy

    H. VALIZADEH, H. TAJERZADEH, and P. ZAKERI MILANI, “COMPARISON OF MASS TRANSFER MODELS FOR DETERMINATION OF THE INTESTINAL PERMEABILITY,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 16, no. 4, pp. 203–210, 2008, [Online]. Available: https://sid.ir/paper/275470/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button