PROTECTIVE EFFECTS OF SETARUD (IMODTM) ON DEVELOPMENT OF DIET-INDUCED HYPERCHOLESTEROLEMIA IN RABBITS

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AZONOV J.A.; KHORAM KHOURSHID H.R.; NOVITSKY Y.A.; FARHADI M.; GHORBAN OUGHLI Z.; SHAH HOSSEINI MOHAMMAD HASAN

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Journal: DARU Journal of Pharmaceutical Sciences Year:2008 | Volume:16 | Issue:4 Page(s): 218-222

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Title

PROTECTIVE EFFECTS OF SETARUD (IMODTM) ON DEVELOPMENT OF DIET-INDUCED HYPERCHOLESTEROLEMIA IN RABBITS

Author(s)

Keywords

HYPERCHOLESTEROLEMIA

IMODTM

SETARUD

Abstract

Background: new herbal drug SETARUD (IMODTM) containing selenium, carotene, and flavonoids, was expected to have positive effects on lipid metabolism and liver functions, due to the nature of its primary components. This study was designed to determine effectiveness of the drug in reducing the risk of development of diet-induced HYPERCHOLESTEROLEMIA in laboratory animals. Methods: Two groups of male rabbits (n=10 per group) as: intact and control groups on regular chow, were fed a high-cholesterol diet, and two experimental groups were maintained on the same diet and treated with different daily doses (0.02 g/kg and 0.04 g/kg) of SETARUD (brand name IMODâ, Pars Roos, Iran). The treatment groups were then compared with the intact and control groups and with one another for the effects of the drug which was determined by changes in blood sugar, serum lipid levels, and liver function tests. Results: Results showed that drug had important benefits in alleviating the impact of highcholesterol diet on serum lipids and liver function markers in drug-treated groups relative to hyperlipidemic controls (p<0.001). A more favorable modification of total cholesterol and triglyceride levels and the atherogenic index was found in animals, which received 0.04 g/kg drug, as compared to the 0.02 g/kg dose group (p<0.05). Assessment of serum total protein, albumin, transaminases, and bilirubin levels showed that no changes in liver function of control and drug-treated animals during the period of the study.Conclusion: From the results of this study it may concluded that SETARUD has dosedependent positive effects on liver and lipid metabolism and may acts as an effective antihyperglycemic agent.

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APA: Copy

AZONOV, J.A., KHORAM KHOURSHID, H.R., NOVITSKY, Y.A., FARHADI, M., GHORBAN OUGHLI, Z., & SHAH HOSSEINI, MOHAMMAD HASAN. (2008). PROTECTIVE EFFECTS OF SETARUD (IMOD^TM) ON DEVELOPMENT OF DIET-INDUCED HYPERCHOLESTEROLEMIA IN RABBITS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 16(4), 218-222. SID. https://sid.ir/paper/275479/en

Vancouver: Copy

AZONOV J.A., KHORAM KHOURSHID H.R., NOVITSKY Y.A., FARHADI M., GHORBAN OUGHLI Z., SHAH HOSSEINI MOHAMMAD HASAN. PROTECTIVE EFFECTS OF SETARUD (IMOD^TM) ON DEVELOPMENT OF DIET-INDUCED HYPERCHOLESTEROLEMIA IN RABBITS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2008;16(4):218-222. Available from: https://sid.ir/paper/275479/en

IEEE: Copy

J.A. AZONOV, H.R. KHORAM KHOURSHID, Y.A. NOVITSKY, M. FARHADI, Z. GHORBAN OUGHLI, and MOHAMMAD HASAN SHAH HOSSEINI, “PROTECTIVE EFFECTS OF SETARUD (IMOD^TM) ON DEVELOPMENT OF DIET-INDUCED HYPERCHOLESTEROLEMIA IN RABBITS,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 16, no. 4, pp. 218–222, 2008, [Online]. Available: https://sid.ir/paper/275479/en

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