THE EFFECT OF INORGANIC CATIONS CA2+ AND AL3+ ON THE RELEASE RATE OF PROPRANOLOL HYDROCHLORIDE FROM SODIUM CARBOXYMETHYLCELLULOSE MATRICES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOHAMMADI G.; BARZEGAR JALALI M.; SIAHI SHADBAD M.R.; AZARMI S.; BARZEGAR JALALI A.; RASEKHIAN M.; ADIBKIA KH.; DANESH BAHREYNI M.A.; KIAFAR F.; ZARE M.; RAEISI R.; HOSSEININASAB S.S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2009 | Volume:17 | Issue:2 Page(s): 131-138

Download Full-Text

View:

348

Download:

131

Cites:

Information Journal Paper

Title

THE EFFECT OF INORGANIC CATIONS CA2+ AND AL3+ ON THE RELEASE RATE OF PROPRANOLOL HYDROCHLORIDE FROM SODIUM CARBOXYMETHYLCELLULOSE MATRICES

Author(s)

Keywords

PROPRANOLOL HYDROCHLORIDE

SODIUM CARBOXYMETHYLCELLULOSE

CA2+ AND AL3+

MATRIX

CROSS- LINKING

Abstract

Background and purpose of the study: Several methods are available for control release of PROPRANOLOL HYDROCHLORIDE (PLH). The aim of the present study was to develop a novel technique to sustain PLH release from matrices.Materials and methods: Matrices of PLH containing SODIUM CARBOXYMETHYLCELLULOSE (Na CMC) and various amounts of the inorganic cations Ca2+ and Al3+ were prepared.Dissolution of the matrices was carried out using the USP apparatus I. Analysis of release data was performed by some model independent and dependent approaches.Results: The release of PLH was affected by incorporation of different amounts (milliequivalents, meq) of Ca2+ and Al3+. When the Ca2+amount increased from 0- 0.375 meq, the fraction of PLH which released within 480 min was augmented from 0.74 to 1 apparently via disintegrating effect of the cation. Al3+ in the range 0- 0.125 meq, decreased the fractional release from 0.74 to 0.37 presumably by in situ CROSS- LINKING with polymer.Al3+ between 0.125 and 0.5 meq enhanced the release from 0.37 to 1 possibly due to the disintegrating effect. Among model independent metrics, the mean release time (MRT) failed to represent the effect of the cations on the release but the release efficiency (RE) as well as a suggested mean release rate (MRR) correlated well with the experimental release rate. Due to the complexity of the release, the only suitable kinetic model was the Weibull distribution. The minimum and maximum Weibull release rate constants for matrices containing Al3+ were 0.0007-0.017 1/min. The corresponding values for the matrices with Ca2+ were 0.0029-0.0082 1/min.Conclusion: Through careful choice of the amount of Al3+ in NaCMC matrices the release of PLH can be controlled at a desired rate. The best model independent approach is MRR and the most accurate model dependent method is Weibull distribution to describe the release data.

Cites

No record.

References

No record.

Cite

APA: Copy

MOHAMMADI, G., BARZEGAR JALALI, M., SIAHI SHADBAD, M.R., AZARMI, S., BARZEGAR JALALI, A., RASEKHIAN, M., ADIBKIA, KH., DANESH BAHREYNI, M.A., KIAFAR, F., ZARE, M., RAEISI, R., & HOSSEININASAB, S.S.. (2009). THE EFFECT OF INORGANIC CATIONS CA²⁺ AND AL³⁺ ON THE RELEASE RATE OF PROPRANOLOL HYDROCHLORIDE FROM SODIUM CARBOXYMETHYLCELLULOSE MATRICES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 17(2), 131-138. SID. https://sid.ir/paper/275503/en

Vancouver: Copy

MOHAMMADI G., BARZEGAR JALALI M., SIAHI SHADBAD M.R., AZARMI S., BARZEGAR JALALI A., RASEKHIAN M., ADIBKIA KH., DANESH BAHREYNI M.A., KIAFAR F., ZARE M., RAEISI R., HOSSEININASAB S.S.. THE EFFECT OF INORGANIC CATIONS CA²⁺ AND AL³⁺ ON THE RELEASE RATE OF PROPRANOLOL HYDROCHLORIDE FROM SODIUM CARBOXYMETHYLCELLULOSE MATRICES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2009;17(2):131-138. Available from: https://sid.ir/paper/275503/en

IEEE: Copy

G. MOHAMMADI, M. BARZEGAR JALALI, M.R. SIAHI SHADBAD, S. AZARMI, A. BARZEGAR JALALI, M. RASEKHIAN, KH. ADIBKIA, M.A. DANESH BAHREYNI, F. KIAFAR, M. ZARE, R. RAEISI, and S.S. HOSSEININASAB, “THE EFFECT OF INORGANIC CATIONS CA²⁺ AND AL³⁺ ON THE RELEASE RATE OF PROPRANOLOL HYDROCHLORIDE FROM SODIUM CARBOXYMETHYLCELLULOSE MATRICES,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 17, no. 2, pp. 131–138, 2009, [Online]. Available: https://sid.ir/paper/275503/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops