SALBUTAMOL SULPHATE-ETHYLCELLULOSE MICRO PARTICLES: FORMULATION AND IN-VITRO EVALUATION WITH EMPHASIS ON MATHEMATICAL APPROACHES

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MURTAZA G.; AHMAD A.; WAHEED ASGHAR A.; NAEEM AMIR M.

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Journal Paper

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Journal: DARU Journal of Pharmaceutical Sciences Year:2009 | Volume:17 | Issue:3 Page(s): 209-216

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Title

SALBUTAMOL SULPHATE-ETHYLCELLULOSE MICRO PARTICLES: FORMULATION AND IN-VITRO EVALUATION WITH EMPHASIS ON MATHEMATICAL APPROACHES

Author(s)

MURTAZA G. | AHMAD A. | WAHEED ASGHAR A. | NAEEM AMIR M. | Issue Writer Certificate

Keywords

SALBUTAMOL SULPHATE

ETHYLCELLULOSE

NON-SOLVENT ADDITION COACERVATION

DISSOLUTION

Abstract

Background and the purpose of the study: This study reports the laboratory optimization for the preparation of SALBUTAMOL SULPHATE-ethyl cellulose micro particles by a NON-SOLVENT ADDITION COACERVATION technique through adjustment of the ratio of SALBUTAMOL SULPHATE to ethyl cellulose. The variation of drug release between the micro particles and tabletted micro particles was also investigated.Methods: In vitro release profiles of developed micro particles and tabletted micro particles were studied using USP XXIV DISSOLUTION apparatus I and II, respectively, in 450 ml double distilled water at 50 rpm maintained at 37oC.Results: White microparticles with no definite shape having good entrapment efficiency (96.68 to 97.83%) and production yield (97.48±1.21 to 98.35±1.08%) were obtained. In this investigation, initial burst effect was observed in the drug release behavior. The rate of drug release from microparticles decreased as the concentration of polyisobutylene was increased from 6% to 12% during microencapsulation. The release pattern of tabletted micro particles was affected significantly (p<0.05) by the addition of hydroxy propyl methyl cellulose (HPMC) as excepient and insignificantly (p>0.05) by the type of DISSOLUTION media and stirring speed. Tabletted micro particles showed good stability and reproducibility. Ethyl cellulose was found to be compatible with SALBUTAMOL SULPHATE. The drug release from all formulations was best fit to Higuchi’s equation and the mechanism of drug release was anomalous diffusion from all formulations.Conclusion: The results of this study suggest that by using ETHYLCELLULOSE it is possible to design a single-unit, sustained-release oral dosage form of SALBUTAMOL SULPHATE for indication of twice a day.

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APA: Copy

MURTAZA, G., AHMAD, A., WAHEED ASGHAR, A., & NAEEM AMIR, M.. (2009). SALBUTAMOL SULPHATE-ETHYLCELLULOSE MICRO PARTICLES: FORMULATION AND IN-VITRO EVALUATION WITH EMPHASIS ON MATHEMATICAL APPROACHES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 17(3), 209-216. SID. https://sid.ir/paper/275517/en

Vancouver: Copy

MURTAZA G., AHMAD A., WAHEED ASGHAR A., NAEEM AMIR M.. SALBUTAMOL SULPHATE-ETHYLCELLULOSE MICRO PARTICLES: FORMULATION AND IN-VITRO EVALUATION WITH EMPHASIS ON MATHEMATICAL APPROACHES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2009;17(3):209-216. Available from: https://sid.ir/paper/275517/en

IEEE: Copy

G. MURTAZA, A. AHMAD, A. WAHEED ASGHAR, and M. NAEEM AMIR, “SALBUTAMOL SULPHATE-ETHYLCELLULOSE MICRO PARTICLES: FORMULATION AND IN-VITRO EVALUATION WITH EMPHASIS ON MATHEMATICAL APPROACHES,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 17, no. 3, pp. 209–216, 2009, [Online]. Available: https://sid.ir/paper/275517/en

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