RAPID ENANTIOSEPARATION OF AMLODIPINE BY HIGHLY SULFATED CYCLODEXTRINS USING SHORT-END INJECTION CAPILLARY ELECTROPHORESIS

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ZANDKARIMI M.; SHAFAATI A.; FOROUTAN S.M.; LUCY CH.A.

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Journal: DARU Journal of Pharmaceutical Sciences Year:2009 | Volume:17 | Issue:4 Page(s): 269-276

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Title

RAPID ENANTIOSEPARATION OF AMLODIPINE BY HIGHLY SULFATED CYCLODEXTRINS USING SHORT-END INJECTION CAPILLARY ELECTROPHORESIS

Author(s)

ZANDKARIMI M. | SHAFAATI A. | FOROUTAN S.M. | LUCY CH.A. | Issue Writer Certificate

Keywords

AMLODIPINE

CHIRAL SEPARATION

HIGHLY SULFATED CYCLODEXTRINS

CARRIER MODE

SHORT-END INJECTION

Abstract

Background and the purpose of the study: The use of HIGHLY SULFATED CYCLODEXTRINS (HS-CDs) as chiral selectors in capillary electrophoresis (CE) has been examined for rapid and reproducible enantioseparation of the model drug AMLODIPINE, a calcium channel blocker. Materials and Methods: Fused silica capillaries with an inner diameter of 50 mm, and a total length of 45.5 cm (8.5 cm to the detector) were used. Capillaries were rinsed with polyethylene oxide (PEO) once daily. A systematic method development approach was conducted by modifying selected parameters such as the type and concentration of the chiral selector, the buffer pH and concentration of the background electrolyte.Results: Baseline separation was achieved at low (i.e. 0.05%w/v) concentrations of HS-aCD, but migration time and peak area repeatability were more than 4% and 25% of the relative standard deviation (RSD), respectively. At higher concentrations (>0.3%) of HS-aCD, AMLODIPINE was transported to the anode by the carrier ability of HS-aCD. In CARRIER MODE, the migration order of enantiomers was reversed, the migration time was reduced and the peak area repeatability of analysis was improved. The optimum electrophoretic conditions for the stereoselective analysis of AMLODIPINE were obtained in CARRIER MODE with 25 mM sodium phosphate buffer containing 1.25% w/v of HS-aCD at pH 2.5 with an applied voltage of +15 kV. Under these conditions migration time was less than 3 min and within-day migration time and peak area repeatability, were less than 0.4% and 2.1% RSD, respectively. Conclusions: Rapid enantioseparation was achieved with minimum variation in quantitative analysis. These optimized conditions are appropriate for the enantioselective analysis of AMLODIPINE.

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APA: Copy

ZANDKARIMI, M., SHAFAATI, A., FOROUTAN, S.M., & LUCY, CH.A.. (2009). RAPID ENANTIOSEPARATION OF AMLODIPINE BY HIGHLY SULFATED CYCLODEXTRINS USING SHORT-END INJECTION CAPILLARY ELECTROPHORESIS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 17(4), 269-276. SID. https://sid.ir/paper/275519/en

Vancouver: Copy

ZANDKARIMI M., SHAFAATI A., FOROUTAN S.M., LUCY CH.A.. RAPID ENANTIOSEPARATION OF AMLODIPINE BY HIGHLY SULFATED CYCLODEXTRINS USING SHORT-END INJECTION CAPILLARY ELECTROPHORESIS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2009;17(4):269-276. Available from: https://sid.ir/paper/275519/en

IEEE: Copy

M. ZANDKARIMI, A. SHAFAATI, S.M. FOROUTAN, and CH.A. LUCY, “RAPID ENANTIOSEPARATION OF AMLODIPINE BY HIGHLY SULFATED CYCLODEXTRINS USING SHORT-END INJECTION CAPILLARY ELECTROPHORESIS,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 17, no. 4, pp. 269–276, 2009, [Online]. Available: https://sid.ir/paper/275519/en

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