RECOMBINANT HUMAN ERYTHROPOIETIN REDUCES PLASMINOGEN ACTIVATOR INHIBITOR AND AMELIORATES PRO-INFLAMMATORY RESPONSES FOLLOWING TRAUMA

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SHIEHMORTEZA M.; AHMADI A.; ABDOLLAHI M.; NAYEBPOUR M.; MOHAMMADI M.; HAMISHEHKAR H.; NAJAFI A.; PAZOKI M.; MOJTAHEDZADEH M.

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Journal: DARU Journal of Pharmaceutical Sciences Year:2011 | Volume:19 | Issue:2 Page(s): 159-165

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Title

RECOMBINANT HUMAN ERYTHROPOIETIN REDUCES PLASMINOGEN ACTIVATOR INHIBITOR AND AMELIORATES PRO-INFLAMMATORY RESPONSES FOLLOWING TRAUMA

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Keywords

ANTI-INFLAMMATORY

ANTI-OXIDATIVE

RECOMBINANT HUMAN ERYTHROPOIETIN

SOFA

TRAUMA

Abstract

Background and the purpose of the study: Besides its hematopoietic effects, erythropoietin (EPO) by mobilization of iron and modulation of some inflammatory cytokines has antioxidant and ANTI-INFLAMMATORY properties. The purpose of this study was to evaluate these effects of erythropoietin and its impact on organ function in TRAUMAtized patients.Methods: Twenty-six ICU-admitted TRAUMAtized patients within 24 hrs after TRAUMA were randomly assigned to the EPO (received EPO, 300 units/Kg/day) and Control (not received EPO) groups. The inflammatory biomarkers including Tumor Necrosis Factor alpha (TNF-a), Interleukin 1 (IL-1), Plasminogen Activator Inhibitor 1 (PAI-1) and Nitrotyrosine were recorded at the admission, 3, 6 and 9 days thereafter. Acute Physiology and Chronic Health Evaluation (APACHE II) and Sequential Organ Failure Assessment (SOFA) scores were also recorded.Results: Among 12 patients (EPO group) TNF-a level at the day of 9 (P=0.046), and within EPO group at the days of 3 (P=0.026 ameliorate), 6 (P=0.016), and 9 (P=0.052) were significantly lowered. Level of IL-1 and PAI-1 decreased significantly at days of 3, 6 and 9 post intervention. Also there were significant differences between two groups in the SOFA score during three measured time intervals (the first, third and seventh days).Conclusion: From the results of this study it seems that injection of erythrocyte stimulating agent is well tolerated and inhibits the inflammatory response and oxidative stress following TRAUMA.

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APA: Copy

SHIEHMORTEZA, M., AHMADI, A., ABDOLLAHI, M., NAYEBPOUR, M., MOHAMMADI, M., HAMISHEHKAR, H., NAJAFI, A., PAZOKI, M., & MOJTAHEDZADEH, M.. (2011). RECOMBINANT HUMAN ERYTHROPOIETIN REDUCES PLASMINOGEN ACTIVATOR INHIBITOR AND AMELIORATES PRO-INFLAMMATORY RESPONSES FOLLOWING TRAUMA. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 19(2), 159-165. SID. https://sid.ir/paper/275602/en

Vancouver: Copy

SHIEHMORTEZA M., AHMADI A., ABDOLLAHI M., NAYEBPOUR M., MOHAMMADI M., HAMISHEHKAR H., NAJAFI A., PAZOKI M., MOJTAHEDZADEH M.. RECOMBINANT HUMAN ERYTHROPOIETIN REDUCES PLASMINOGEN ACTIVATOR INHIBITOR AND AMELIORATES PRO-INFLAMMATORY RESPONSES FOLLOWING TRAUMA. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2011;19(2):159-165. Available from: https://sid.ir/paper/275602/en

IEEE: Copy

M. SHIEHMORTEZA, A. AHMADI, M. ABDOLLAHI, M. NAYEBPOUR, M. MOHAMMADI, H. HAMISHEHKAR, A. NAJAFI, M. PAZOKI, and M. MOJTAHEDZADEH, “RECOMBINANT HUMAN ERYTHROPOIETIN REDUCES PLASMINOGEN ACTIVATOR INHIBITOR AND AMELIORATES PRO-INFLAMMATORY RESPONSES FOLLOWING TRAUMA,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 19, no. 2, pp. 159–165, 2011, [Online]. Available: https://sid.ir/paper/275602/en

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