مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

282
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

321
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

FORMULATION AND EVALUATION OF OLANZAPINE MATRIX PELLETS FOR CONTROLLED RELEASE

Pages

  249-256

Abstract

 Background and the purpose of the study: Olanzapine is an antipsychotic used in treatment of schizophrenia. This research was carried out to design oral controlled release matrix pellets of water insoluble drug Olanzapine (OZ), using blend of Sodium Alginate (SA) and Glyceryl Palmito-Stearate (GPS) as matrix polymers, micro crystalline cellulose (MCC) as spheronizer enhancer and Sodium Lauryl Sulphate (SLS) as pore forming agent.Methods: OZ formulations were developed by the PELLETIZATION technique by drug loaded pellets and characterized with regard to the drug content, size distribution, Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR) and X-ray Diffraction study (XRD). Stability studies were carried out on the optimized formulation for a period of 90 days at 40 ± 2°C and 75 ± 5% relative humidity.Results and major conclusion: The drug content was in the range of 93.34-98.12 %. The mean particle size of the drug loaded pellets was in the range 1024 to 1087mm. SEM photographs and calculated sphericity factor confirmed that the prepared formulations were spherical in nature. The compatibility between drug and polymers in the drug loaded pellets was confirmed by DSC and FTIR studies. Stability studies indicated that pellets are stable. XRD patterns revealed the crystalline nature of the pure OZ. Loose surface crystal study indicated that crystalline OZ is present in all formulations and more clear in formulation F5. Drug release was controlled for more than 24 hrs and mechanism of the drug release followed by Fickian diffusion. It may be concluded that F5 is an ideal formulation for once a day administration.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    GUPTA, N. VISHAL, GOWDA, D.V., BALAMURALIDHARA, V., & MOHAMMED KHAN, S.. (2011). FORMULATION AND EVALUATION OF OLANZAPINE MATRIX PELLETS FOR CONTROLLED RELEASE. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 19(4), 249-256. SID. https://sid.ir/paper/275617/en

    Vancouver: Copy

    GUPTA N. VISHAL, GOWDA D.V., BALAMURALIDHARA V., MOHAMMED KHAN S.. FORMULATION AND EVALUATION OF OLANZAPINE MATRIX PELLETS FOR CONTROLLED RELEASE. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2011;19(4):249-256. Available from: https://sid.ir/paper/275617/en

    IEEE: Copy

    N. VISHAL GUPTA, D.V. GOWDA, V. BALAMURALIDHARA, and S. MOHAMMED KHAN, “FORMULATION AND EVALUATION OF OLANZAPINE MATRIX PELLETS FOR CONTROLLED RELEASE,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 19, no. 4, pp. 249–256, 2011, [Online]. Available: https://sid.ir/paper/275617/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button