EFFECTS OF RUTIN ON ACRYLAMIDE-INDUCED NEUROTOXICITY

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MOTAMEDSHARIATY VAHIDEHSADAT; AMEL FARZAD SARA; NASIRI ASL MARJAN; HOSSEINZADEH HOSSEIN

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Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2014 | Volume:22 | Issue:2 Page(s): 1-9

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Title

EFFECTS OF RUTIN ON ACRYLAMIDE-INDUCED NEUROTOXICITY

Author(s)

MOTAMEDSHARIATY VAHIDEHSADAT | AMEL FARZAD SARA | NASIRI ASL MARJAN | HOSSEINZADEH HOSSEIN | Issue Writer Certificate

Keywords

RUTIN

ACRYLAMIDE

MTT ASSAY

NEURAL TOXICITY

ANTIOXIDANT

Abstract

Background: RUTIN is an important flavonoid that is consumed in the daily diet. The cytoprotective effects of RUTIN, including antioxidative, and neuroprotective have been shown in several studies. Neurotoxic effects of ACRYLAMIDE (ACR) have been established in humans and animals. In this study, the protective effects of RUTIN in prevention and treatment of NEURAL TOXICITY of ACR were studied.Results: RUTIN significantly reduced cell death induced by ACR (5.46 mM) in time-and dose-dependent manners.RUTIN treatment decreased the ACR-induced cytotoxicity significantly in comparison to control (P<0.01, P<0.001).RUTIN (100 and 200 mg/kg) could prevent decrease of body weight in rats. In combination treatments with RUTIN (50, 100 and 200 mg/kg), vitamin E (200 mg/kg) and ACR, gait abnormalities significantly decreased in a dosedependent manner (P<0.01 and P<0.001). The level of malondialdehyde significantly decreased in the brain tissue of rats in both preventive and therapeutic groups that received RUTIN (100 and 200 mg/kg).Conclusion: It seems that RUTIN could be effective in reducing neurotoxicity and the neuroprotective effect of it might be mediated via ANTIOXIDANT activity.

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APA: Copy

MOTAMEDSHARIATY, VAHIDEHSADAT, AMEL FARZAD, SARA, NASIRI ASL, MARJAN, & HOSSEINZADEH, HOSSEIN. (2014). EFFECTS OF RUTIN ON ACRYLAMIDE-INDUCED NEUROTOXICITY. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 22(2), 1-9. SID. https://sid.ir/paper/275715/en

Vancouver: Copy

MOTAMEDSHARIATY VAHIDEHSADAT, AMEL FARZAD SARA, NASIRI ASL MARJAN, HOSSEINZADEH HOSSEIN. EFFECTS OF RUTIN ON ACRYLAMIDE-INDUCED NEUROTOXICITY. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2014;22(2):1-9. Available from: https://sid.ir/paper/275715/en

IEEE: Copy

VAHIDEHSADAT MOTAMEDSHARIATY, SARA AMEL FARZAD, MARJAN NASIRI ASL, and HOSSEIN HOSSEINZADEH, “EFFECTS OF RUTIN ON ACRYLAMIDE-INDUCED NEUROTOXICITY,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 22, no. 2, pp. 1–9, 2014, [Online]. Available: https://sid.ir/paper/275715/en

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