SHORT COMMUNICATION: PHARMACOKINETICS OF MIRTAZAPINE AND ITS MAIN METABOLITES AFTER SINGLE INTRAVENOUS AND ORAL ADMINISTRATIONS IN RATS AT TWO DOSE RATES

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ROUINI MOHAMMAD REZA; LAVASANI HODA; SHEIKHOLESLAMI BEHJAT; OWEN HELEN; GIORGI MARIO

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Journal: DARU Journal of Pharmaceutical Sciences Year:2014 | Volume:22 | Issue:1 Page(s): 1-5

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Title

SHORT COMMUNICATION: PHARMACOKINETICS OF MIRTAZAPINE AND ITS MAIN METABOLITES AFTER SINGLE INTRAVENOUS AND ORAL ADMINISTRATIONS IN RATS AT TWO DOSE RATES

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Keywords

MIRTAZAPINE

METABOLITES

RATS

PHARMACOKINETICS

BIOAVAILABILITY

Abstract

Background: MIRTAZAPINE (MRZ) is a human antidepressant drug metabolized to 8-OH MIRTAZAPINE (8-OH) and dimethylMIRTAZAPINE (DMR) METABOLITES. Recently, this drug has been proposed as a potential analgesic for use in a multidrug analgesic regime in the context of veterinary medicine. The aim of this study was to assess the PHARMACOKINETICS of MRZ and its METABOLITES DMR and 8-OH in RATS.Findings: Eighteen fasted, healthy male RATS were randomly divided into 3 groups (n=6). Animals in these groups were respectively administered MRZ at 2 and 10 mg/kg orally and 2 mg/kg intravenously. Plasma MRZ and metabolite concentrations were evaluated by HPLC-FL detection method. After intravenous administration, MRZ was detected in all subjects, while DMR was only detected in three.8-OH was not detected. After oral administration, MRZ was detected in 3 out of 6 RATS treated with 2 mg/kg, it was detected in 6 out of 6 animals in the 10 mg/kg group.DMR was only detectable in the latter group, while 8-OH was not detected in either group. The oral BIOAVAILABILITY was about 7% in both groups.Conclusions: The plasma concentration of the MRZ metabolite 8-OH was undetectable, and the oral BIOAVAILABILITY of the parental drug was very low.

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APA: Copy

ROUINI, MOHAMMAD REZA, LAVASANI, HODA, SHEIKHOLESLAMI, BEHJAT, OWEN, HELEN, & GIORGI, MARIO. (2014). SHORT COMMUNICATION: PHARMACOKINETICS OF MIRTAZAPINE AND ITS MAIN METABOLITES AFTER SINGLE INTRAVENOUS AND ORAL ADMINISTRATIONS IN RATS AT TWO DOSE RATES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 22(1), 1-5. SID. https://sid.ir/paper/275727/en

Vancouver: Copy

ROUINI MOHAMMAD REZA, LAVASANI HODA, SHEIKHOLESLAMI BEHJAT, OWEN HELEN, GIORGI MARIO. SHORT COMMUNICATION: PHARMACOKINETICS OF MIRTAZAPINE AND ITS MAIN METABOLITES AFTER SINGLE INTRAVENOUS AND ORAL ADMINISTRATIONS IN RATS AT TWO DOSE RATES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2014;22(1):1-5. Available from: https://sid.ir/paper/275727/en

IEEE: Copy

MOHAMMAD REZA ROUINI, HODA LAVASANI, BEHJAT SHEIKHOLESLAMI, HELEN OWEN, and MARIO GIORGI, “SHORT COMMUNICATION: PHARMACOKINETICS OF MIRTAZAPINE AND ITS MAIN METABOLITES AFTER SINGLE INTRAVENOUS AND ORAL ADMINISTRATIONS IN RATS AT TWO DOSE RATES,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 22, no. 1, pp. 1–5, 2014, [Online]. Available: https://sid.ir/paper/275727/en

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