UNRAVELING THE CYTOTOXIC POTENTIAL OF TEMOZOLOMIDE LOADED INTO PLGA NANOPARTICLES

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JAIN DARSHANA S.; ATHAWALE RAJANI B.; BAJAJ AMRITA N.; SHRIKHANDE SHRUTI S.; GOEL PEEYUSH N.; NIKAM YUVRAJ; GUDE RAJIV P.

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Journal Paper

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Journal: DARU Journal of Pharmaceutical Sciences Year:2014 | Volume:22 | Issue:1 Page(s): 1-9

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Title

UNRAVELING THE CYTOTOXIC POTENTIAL OF TEMOZOLOMIDE LOADED INTO PLGA NANOPARTICLES

Author(s)

Keywords

C6 CELL LINE

GLIOMAS

PLGA NANOPARTICLES

TEMOZOLOMIDE

Abstract

Background: Nanotechnology has received great attention since a decade for the treatment of different varieties of cancer. However, there is a limited data available on the cytotoxic potential of TEMOZOLOMIDE (TMZ) formulations. In the current research work, an attempt has been made to understand the anti-metastatic effect of the drug after loading into PLGA NANOPARTICLES against C6 glioma cells.Nanoparticles were prepared using solvent diffusion method and were characterized for size and morphology.Diffusion of the drug from the nanoparticles was studied by dialysis method. The designed nanoparticles were also assessed for cellular uptake using confocal microscopy and flow cytometry.Results: PLGA NANOPARTICLES caused a sustained release of the drug and showed a higher cellular uptake. The drug formulations also affected the cellular proliferation and motility.Conclusion: PLGA coated nanoparticles prolong the activity of the loaded drug while retaining the anti-metastatic activity.

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APA: Copy

JAIN, DARSHANA S., ATHAWALE, RAJANI B., BAJAJ, AMRITA N., SHRIKHANDE, SHRUTI S., GOEL, PEEYUSH N., NIKAM, YUVRAJ, & GUDE, RAJIV P.. (2014). UNRAVELING THE CYTOTOXIC POTENTIAL OF TEMOZOLOMIDE LOADED INTO PLGA NANOPARTICLES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 22(1), 1-9. SID. https://sid.ir/paper/275729/en

Vancouver: Copy

JAIN DARSHANA S., ATHAWALE RAJANI B., BAJAJ AMRITA N., SHRIKHANDE SHRUTI S., GOEL PEEYUSH N., NIKAM YUVRAJ, GUDE RAJIV P.. UNRAVELING THE CYTOTOXIC POTENTIAL OF TEMOZOLOMIDE LOADED INTO PLGA NANOPARTICLES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2014;22(1):1-9. Available from: https://sid.ir/paper/275729/en

IEEE: Copy

DARSHANA S. JAIN, RAJANI B. ATHAWALE, AMRITA N. BAJAJ, SHRUTI S. SHRIKHANDE, PEEYUSH N. GOEL, YUVRAJ NIKAM, and RAJIV P. GUDE, “UNRAVELING THE CYTOTOXIC POTENTIAL OF TEMOZOLOMIDE LOADED INTO PLGA NANOPARTICLES,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 22, no. 1, pp. 1–9, 2014, [Online]. Available: https://sid.ir/paper/275729/en

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