SYNTHESIS AND PSYCHOBIOLOGICAL EVALUATION OF MODAFINIL ANALOGS IN MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

LARI AREZOU; KARIMI ISAAC; ADIBI HADI; ALIABADI ALIREZA; FIROOZPOUR LOGHMAN; FOROUMADI ALIREZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2013 | Volume:21 | Issue:9 Page(s): 1-8

Download Full-Text

View:

348

Download:

152

Cites:

Information Journal Paper

Title

SYNTHESIS AND PSYCHOBIOLOGICAL EVALUATION OF MODAFINIL ANALOGS IN MICE

Author(s)

Keywords

MODAFINIL

WAKE-PROMOTING AGENT

NARCOLEPSY

Abstract

Background and the purpose of the study: MODAFINIL, a novel WAKE-PROMOTING AGENT with low potential for abuse and dependence, has a reliable structure to find some novel derivatives with better activity and lower potential for abuse and risk of dependency. This study was designed to evaluate psychobiological activity of some novel N-aryl MODAFINIL derivatives.Methods: Seven novel N-aryl MODAFINIL derivatives were synthesized through three reactions: a) preparation of benzhydrylsulfanyl acetic acid through reaction of benzhydrol with thioglycolic acid, b) formation of desired amide by adding the substituted aniline to activated acid with EDC (1-ethyl-3- (3-dimethyl amino propyl) carbodiimide). This reaction was catalyzed by HOBt (N- hydroxylbenzotriazole), and c) oxidation of sulfur to sulfoxide group with H2O2.Then, their psychobiological effect on the performance of male albino mice were compared to that of MODAFINIL as following: wakefulness by determining the effects of derivatives on phenobarbital-induced loss of the righting reflex (LOPR); exploratory activity by measuring activity in the open field test (OFT); depression by measuring immobility time (IT) during forced swimming test (FST) and the anxiogenic and anxiolytic like effects by using elevated plus-maze test (EPM). All tests were videotaped and analyzed for the frequency and duration of the behaviors during the procedures.Conclusions: 2- (Benzhydrylsulfonyl) -N- (4-chlorophenyl) acetamide (4c) showed comparable result in LOPR test.However, all analogs were found to be stimulant except 2- (benzhydrylsulfinyl) -N-phenylacetamide (4a). Also 4c led the most exploratory activity in mice among derivatives. FST results showed that 4a had the longest IT while MODAFINIL, 2- (benzhydrylsulfinyl) -N- (3-chlorophenyl) acetamide (4b) and 2- (benzhydrylsulfinyl) -N- (4-ethylphenyl) acetamide (4d) had the shortest IT. In EPM, all derivatives showed anxiogenic-like behavior since they decreased open arms time and open arms entries and simultaneously increased close arms time.

Cites

No record.

References

No record.

Cite

APA: Copy

LARI, AREZOU, KARIMI, ISAAC, ADIBI, HADI, ALIABADI, ALIREZA, FIROOZPOUR, LOGHMAN, & FOROUMADI, ALIREZA. (2013). SYNTHESIS AND PSYCHOBIOLOGICAL EVALUATION OF MODAFINIL ANALOGS IN MICE. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 21(9), 1-8. SID. https://sid.ir/paper/275745/en

Vancouver: Copy

LARI AREZOU, KARIMI ISAAC, ADIBI HADI, ALIABADI ALIREZA, FIROOZPOUR LOGHMAN, FOROUMADI ALIREZA. SYNTHESIS AND PSYCHOBIOLOGICAL EVALUATION OF MODAFINIL ANALOGS IN MICE. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2013;21(9):1-8. Available from: https://sid.ir/paper/275745/en

IEEE: Copy

AREZOU LARI, ISAAC KARIMI, HADI ADIBI, ALIREZA ALIABADI, LOGHMAN FIROOZPOUR, and ALIREZA FOROUMADI, “SYNTHESIS AND PSYCHOBIOLOGICAL EVALUATION OF MODAFINIL ANALOGS IN MICE,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 21, no. 9, pp. 1–8, 2013, [Online]. Available: https://sid.ir/paper/275745/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops