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Information Journal Paper

Title

THE EFFICACY OF IMPLANT OF OCTACALCIUM PHOSPHATE IN COMBINATION WITH BONE MATRIX GELATIN ON BONE REGENERATION IN SKULL DEFECTS IN RAT

Pages

  124-129

Abstract

 Background: In several conditions we have face cranial bone defects. Reconstruction of these defects remains one of the most challenging problems encountered by craniofacial surgeons. Objective: To evaluate bone repair in cranial bone defects by use of an implant made of octacalcium phosphate in combination with bone matrix gelatin (OCP/BMG). Methods: We used 40, 5–6-week-old male Sprague-Dawley rats. A full thickness standardized trephine defect—5-mm in diameter—was made in the rat parietal bone and OCP/BMG was implanted into the defect. No OCP/BMG particles were implanted in control group that was otherwise treated identically. After sacrificing the rats chronologically and processing the tissues by routine histological procedures, 5-mm thick sections of bone were stained and examined under light microscope. Results: On the 5th day of implantation, inflammatory cells were seen around the implanted materials, especially around the OCP particles. By the end of 21st day, almost all of the OCP/BMG particles were absorbed and bone trabeculae, bone marrow cavities and bone marrow tissues were seen. In the control group, at the end of 21th day, a few areas of new bone were seen near to the defect margins and host bone, however, in much less amount than in the experimental group. Conclusion: Implant of OCP/BMG appears to stimulate new bone regeneration in bone defects. These biomaterials can be used for repair of cranial bone defects.

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    APA: Copy

    SARGOLZAEI AVAL, F., SOBHANI, A., ARAB, M.R., SARANI, S.A., & HEYDARI, M.H.. (2004). THE EFFICACY OF IMPLANT OF OCTACALCIUM PHOSPHATE IN COMBINATION WITH BONE MATRIX GELATIN ON BONE REGENERATION IN SKULL DEFECTS IN RAT. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 29(3), 124-129. SID. https://sid.ir/paper/275831/en

    Vancouver: Copy

    SARGOLZAEI AVAL F., SOBHANI A., ARAB M.R., SARANI S.A., HEYDARI M.H.. THE EFFICACY OF IMPLANT OF OCTACALCIUM PHOSPHATE IN COMBINATION WITH BONE MATRIX GELATIN ON BONE REGENERATION IN SKULL DEFECTS IN RAT. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2004;29(3):124-129. Available from: https://sid.ir/paper/275831/en

    IEEE: Copy

    F. SARGOLZAEI AVAL, A. SOBHANI, M.R. ARAB, S.A. SARANI, and M.H. HEYDARI, “THE EFFICACY OF IMPLANT OF OCTACALCIUM PHOSPHATE IN COMBINATION WITH BONE MATRIX GELATIN ON BONE REGENERATION IN SKULL DEFECTS IN RAT,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 29, no. 3, pp. 124–129, 2004, [Online]. Available: https://sid.ir/paper/275831/en

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