ASSESSMENT OF THYROID GLAND OF FUNCTION DURING INTERFERON ALFA THERAPY IN PATIENTS WITH HBV OR HCV

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ESFAHANIAN F.; ZEYAEI A.; ALAVIAN S.M.

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Journal Paper

Paper Information

Journal: Iranian Journal of Endocrinology & Metabolism Year:2005 | Volume:7 | Issue:3 (SN 27) Page(s): 223-229

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Title

ASSESSMENT OF THYROID GLAND OF FUNCTION DURING INTERFERON ALFA THERAPY IN PATIENTS WITH HBV OR HCV

Author(s)

ESFAHANIAN F. | ZEYAEI A. | ALAVIAN S.M. | Issue Writer Certificate

Keywords

HYPERTHYROIDISMQ4

HYPOTHYROIDISM INF-ΑQ3

THYROIDITISM TGABSQ4

TPO ABSQ4

Abstract

Aim: To evaluate thyroid gland dysfunction during interferon alfa (INF-alpha) therapy in patients with the hepatitis B ( HBV)and hepatitis C virus (HCV). Materials and Methods: 58 patients HCV and 18 patients with HBV were studied prospectively before and at 2 months intervals during INF-alpha therapy. Measurements of serum thyroxine, triiodothyronine, thyrotropine, triiodothyronine resin uptake, thyroid peroxidase antibodies (TPOAbs), and thyroglobulin antibodies (TgAbs) were obtained as were. Thyroid radioactive ioidine uptakes (RAIU) in patients who developed thyroxicosis. Thyroid gland size was evaluated with palpation. Results: All patients were clinically and biochemically euthyroid prior to INF-alpha therapy. Before treatment, positive levels of TPOAbs and TgAbs were found in 13.8% and 8.6% of patients with HCV compared with 5.5% and 5.5% of patients with HBV, respectively. Titers of TPOAbs increased significantly at the end of INF-alpha therapy in patients with HCV(!0.3%),among whom 5 patients developed hypothyroidism and 1 patient became thyrotoxic secondary to thyroiditis with low. thyroid RAIU. Patients who developed thyroid gland dysfunction had a higher prevalence of TPOAbs before treatment. Thyroid gland size increased significantly during the study in patients with HBV (p<0.001) and HCV(p<0.005) respectively. Conclusions: Thyroid gland dysfunction is not infrequently observed in patients with HCV receiving INF -alpha therapy. Systematic screening of thyroid function and TPOAbs titers in all patients with HCV before and during INF-alpha therapy seems warranted are recommended, should INF-alpha have goiterogenic effects; further studies are recommended.

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APA: Copy

ESFAHANIAN, F., ZEYAEI, A., & ALAVIAN, S.M.. (2005). ASSESSMENT OF THYROID GLAND OF FUNCTION DURING INTERFERON ALFA THERAPY IN PATIENTS WITH HBV OR HCV. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 7(3 (SN 27)), 223-229. SID. https://sid.ir/paper/27584/en

Vancouver: Copy

ESFAHANIAN F., ZEYAEI A., ALAVIAN S.M.. ASSESSMENT OF THYROID GLAND OF FUNCTION DURING INTERFERON ALFA THERAPY IN PATIENTS WITH HBV OR HCV. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2005;7(3 (SN 27)):223-229. Available from: https://sid.ir/paper/27584/en

IEEE: Copy

F. ESFAHANIAN, A. ZEYAEI, and S.M. ALAVIAN, “ASSESSMENT OF THYROID GLAND OF FUNCTION DURING INTERFERON ALFA THERAPY IN PATIENTS WITH HBV OR HCV,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 7, no. 3 (SN 27), pp. 223–229, 2005, [Online]. Available: https://sid.ir/paper/27584/en

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