مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

THE EXPRESSION AND PROGNOSTIC SIGNIFICANCE OF C-ERBB-2 MOLECULES IN PATIENTS WITH BREAST CANCER IN IRAN

Pages

  31-35

Abstract

 Background: Epidermal growth factor receptors (EGFRs) are a group of molecules with structural and functional similarities, which are expressed in some breast cancers. In the present investigation, the presence of two members of the EGFR family namely c-erbB-1 and c-erbB-2 was assessed as a prognostic indicator in a series of breast tumors. Objective: To study the over-expression of c-erbB-1 and c-erbB-2 in a series of primary breast cancer as a prognostic factor. Methods: A series of 100 patients with primary operable breast cancers were investigated for expression of EGFRs in their tumors by immunocytochemical staining with the monoclonal antibodies against erbB-1 and erbB-2 molecules. An indirect immunoperoxidase method was used for determination of these receptors in formalin-fixed paraffin-embedded breast carcinoma tissues. This technique was also used to investigate the expression of c-erbB-1 and 2 in 23 out of the 100 fresh frozen tissues of breast carcinoma. Results: Our results indicate that 20 (20%) and 41 (41%) tumors showed positive immunoreactivity with erbB-1 and erbB-2 monoclonal antibodies, respectively. Results also indicated that in 100% of cases the pattern of immunoreactivity in fresh tissues were comparable with those of the formalin-fixed paraffin embedded tissues. Strong correlation between distinct c-erbB-2 expression and short disease-free interval was observed but no significant association was found with c-erbB-1. Conclusion: The results show that the c-erbB-2 receptor status may be a useful prognostic marker in breast cancer.

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    APA: Copy

    GHARESIFARD, B., VASEEI, M., TALEI, A., MOJTAHEDI, H., DEAN, C., & GHADERI, A.. (2000). THE EXPRESSION AND PROGNOSTIC SIGNIFICANCE OF C-ERBB-2 MOLECULES IN PATIENTS WITH BREAST CANCER IN IRAN . IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 25(1-2), 31-35. SID. https://sid.ir/paper/275889/en

    Vancouver: Copy

    GHARESIFARD B., VASEEI M., TALEI A., MOJTAHEDI H., DEAN C., GHADERI A.. THE EXPRESSION AND PROGNOSTIC SIGNIFICANCE OF C-ERBB-2 MOLECULES IN PATIENTS WITH BREAST CANCER IN IRAN . IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2000;25(1-2):31-35. Available from: https://sid.ir/paper/275889/en

    IEEE: Copy

    B. GHARESIFARD, M. VASEEI, A. TALEI, H. MOJTAHEDI, C. DEAN, and A. GHADERI, “THE EXPRESSION AND PROGNOSTIC SIGNIFICANCE OF C-ERBB-2 MOLECULES IN PATIENTS WITH BREAST CANCER IN IRAN ,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 25, no. 1-2, pp. 31–35, 2000, [Online]. Available: https://sid.ir/paper/275889/en

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