PRIMARY ANTIPHOSPHOLIPID SYNDROME; DIFFERENTIATION FROM MULTIPLE SCLEROSIS A STUDY OF 22 CASES

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NIKSERESHT A.R.; REZAEIAN GH. R.; HAKIM M.

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Paper Information

Journal: IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS) Year:2000 | Volume:25 | Issue:1-2 Page(s): 50-55

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Title

PRIMARY ANTIPHOSPHOLIPID SYNDROME; DIFFERENTIATION FROM MULTIPLE SCLEROSIS A STUDY OF 22 CASES

Author(s)

NIKSERESHT A.R. | REZAEIAN GH. R. | HAKIM M. | Issue Writer Certificate

Keywords

ANTIPHOSPHOLIPID SYNDROME • ANTIBODIES

ANTIPHOSPHOLIPID • MULTIPLE SCLEROSIS

Abstract

Background/Objective: Anti-phospholipid syndrome (APS) is a well-known cause of thrombosis and can mimic multiple sclerosis (MS). We analyzed the neurologic manifestation, laboratory and MRI findings of our patients with primary APS (PAPS) in an attempt to identify parameters that might differentiate the two entities. Methods: Of 180 cases with the diagnosis of probable or definite MS, we studied 29 patients who had symptoms suggesting an underlying systemic disease, unusual laboratory findings or atypical evolution for MS. Of these, 22 patients (15 female and 7 male, mean age 30 year) proved to have PAPS with antiphospholipid antibody (aPL) positivity (titer 10 GPL units) and were followed-up for at least 8 months. Brain MRI was performed in all of the patients. Results: The most frequent initial manifestations were paresis (10 cases) and cerebellar signs (4 cases). During the established stage, 15 cases had paresis; and cerebellar signs, depression and sensory disturbance were seen in 10, 9 and 8 patients respectively. High ESR, thrombocytopenia and prolonged partial thromboplastin time (PTT) were detected in 8, 4 and 3 patients respectively. MRI of the brain showed multiple lesions in 15 and a single lesion in 7 cases. Also 4 of the female patients had a history of unexplained fetal loss. Conclusion: We believe that all cases with the initial impression of MS who present with systemic or laboratory features of APS or a history of unexplained fetal loss should be screened for the presence of aPL, and APS should be considered as an alternative diagnosis to MS.

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APA: Copy

NIKSERESHT, A.R., REZAEIAN, GH. R., & HAKIM, M.. (2000). PRIMARY ANTIPHOSPHOLIPID SYNDROME; DIFFERENTIATION FROM MULTIPLE SCLEROSIS A STUDY OF 22 CASES. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 25(1-2), 50-55. SID. https://sid.ir/paper/275890/en

Vancouver: Copy

NIKSERESHT A.R., REZAEIAN GH. R., HAKIM M.. PRIMARY ANTIPHOSPHOLIPID SYNDROME; DIFFERENTIATION FROM MULTIPLE SCLEROSIS A STUDY OF 22 CASES. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2000;25(1-2):50-55. Available from: https://sid.ir/paper/275890/en

IEEE: Copy

A.R. NIKSERESHT, GH. R. REZAEIAN, and M. HAKIM, “PRIMARY ANTIPHOSPHOLIPID SYNDROME; DIFFERENTIATION FROM MULTIPLE SCLEROSIS A STUDY OF 22 CASES,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 25, no. 1-2, pp. 50–55, 2000, [Online]. Available: https://sid.ir/paper/275890/en

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