CORRELATION BETWEEN PITUITARY MRI AND HYPOGONADOTROPIC HYPOGONADISM IN THALASSEMIA

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RASEKHI AL.R.; BAGHERI M.H.; SADEGH ALVAD A.A.S.; OMRANI G.H.; RASEKHI AH.R.

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Journal: IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS) Year:2000 | Volume:25 | Issue:1-2 Page(s): 21-24

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Title

CORRELATION BETWEEN PITUITARY MRI AND HYPOGONADOTROPIC HYPOGONADISM IN THALASSEMIA

Author(s)

Keywords

THALASSEMIA MRI PITUITARY GLAND HYPOGONADISM

HYPOGONADOTROPIC

Abstract

Background: The thalassemias are among the most prevalent genetic diseases worldwide. There is a high incidence of thalassemia in Iran; one of the countries located on the so-called "thalassemia belt". Repeated blood transfusion in thalassemia may cause iron deposition in many tissues including endocrine organs. Objective: To study the pituitary changes in ?thalassemia detected by MRI in correlation with hormonal changes. Methods: Thirty-six patients with thalassemia major with mean age of 17.8 3 years (17 male and 19 female) were enrolled in this study. The control group comprised of 20 (10 male and 10 female) age- and sex-matched individuals. All of the patients and controls underwent clinical examination, hormonal study and MRI of the pituitary gland. Results: Forty-seven percent of the girls and 53% of the boys with thalassemia major had small size pituitary gland. Fifty-three percent of the boys and 58% of the girls patients had low pituitary signal in T2 weighted image. Seventy-eight per cent of the patients had HYPOGONADOTROPIC hypogonadism (H.H). There was a statistically significant correlation between low hormonal level (H.H) and both low pituitary signal (P<0.012) and small pituitary size (P<0.04). Conclusion: A significant percent of thalassemic patients show small size and hyposignal pituitary gland in sagittal and coronal T2 weighted MRI images which have a statically significant correlation with hormonal deficiency and pituitary dysfunction.

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APA: Copy

RASEKHI, AL.R., BAGHERI, M.H., SADEGH ALVAD, A.A.S., OMRANI, G.H., & RASEKHI, AH.R.. (2000). CORRELATION BETWEEN PITUITARY MRI AND HYPOGONADOTROPIC HYPOGONADISM IN THALASSEMIA. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 25(1-2), 21-24. SID. https://sid.ir/paper/275891/en

Vancouver: Copy

RASEKHI AL.R., BAGHERI M.H., SADEGH ALVAD A.A.S., OMRANI G.H., RASEKHI AH.R.. CORRELATION BETWEEN PITUITARY MRI AND HYPOGONADOTROPIC HYPOGONADISM IN THALASSEMIA. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2000;25(1-2):21-24. Available from: https://sid.ir/paper/275891/en

IEEE: Copy

AL.R. RASEKHI, M.H. BAGHERI, A.A.S. SADEGH ALVAD, G.H. OMRANI, and AH.R. RASEKHI, “CORRELATION BETWEEN PITUITARY MRI AND HYPOGONADOTROPIC HYPOGONADISM IN THALASSEMIA,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 25, no. 1-2, pp. 21–24, 2000, [Online]. Available: https://sid.ir/paper/275891/en

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