IGG SUBCLASS ANALYSIS OF ANTI-HBS ANTIBODIES PRODUCED IN RESPONSE TO VACCINATION WITH RECOMBINANT HBSAG AND INFECTION WITH THE WILD HEPATITIS B VIRUS

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IZAD M.; SHOKRI F.; JEFFERIS R.

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Paper Information

Journal: IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS) Year:2000 | Volume:25 | Issue:1-2 Page(s): 42-49

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Title

IGG SUBCLASS ANALYSIS OF ANTI-HBS ANTIBODIES PRODUCED IN RESPONSE TO VACCINATION WITH RECOMBINANT HBSAG AND INFECTION WITH THE WILD HEPATITIS B VIRUS

Author(s)

IZAD M. | SHOKRI F. | JEFFERIS R. | Issue Writer Certificate

Keywords

HEPATITIS B VIRUS • VACCINATION • HEPATITIS B ANTIBODIES • IGG

Abstract

Background: Viral hepatitis, particularly hepatitis B virus (HBV) infection remains a major public health problem worldwide and different profiles of IgG subclasses of anti-HBs antibody have been reported to be produced in individuals infected with HBV and those vaccinated with HBsAg. Objective: To evaluate the difference among various profiles of IgG subclasses produced in response to HBV infection and HBsAg observed in HBV positive patients and those vaccinated with HBsAg. Methods: Antibody to hepatitis B surface antigen (HBsAg) was purified by affinity chromatography from sera of 24 normal individuals vaccinated with recombinant HBsAg (rHBsAg) and 18 persons infected with hepatitis B virus (HBV). The isotype and IgG subclass profiles of the purified anti-HBs antibodies were determined by enzyme-linked immunosorbent assay (ELISA) using plates pre-coated with rHBsAg and isotype specific monoclonal antibodies. Results: IgG2 was the predominant subclass of anti-HBs antibody in both groups of individuals followed by IgG4 and IgG1. IgG3 was hardly detectable in the majority of samples tested. Conclusion: No significant differences were observed between the two subject groups with regards to the levels of IgG subclasses and isotypes, suggesting similar antibody responses to rHBsAg and the wild type HBV.

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APA: Copy

IZAD, M., SHOKRI, F., & JEFFERIS, R.. (2000). IGG SUBCLASS ANALYSIS OF ANTI-HBS ANTIBODIES PRODUCED IN RESPONSE TO VACCINATION WITH RECOMBINANT HBSAG AND INFECTION WITH THE WILD HEPATITIS B VIRUS. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 25(1-2), 42-49. SID. https://sid.ir/paper/275893/en

Vancouver: Copy

IZAD M., SHOKRI F., JEFFERIS R.. IGG SUBCLASS ANALYSIS OF ANTI-HBS ANTIBODIES PRODUCED IN RESPONSE TO VACCINATION WITH RECOMBINANT HBSAG AND INFECTION WITH THE WILD HEPATITIS B VIRUS. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2000;25(1-2):42-49. Available from: https://sid.ir/paper/275893/en

IEEE: Copy

M. IZAD, F. SHOKRI, and R. JEFFERIS, “IGG SUBCLASS ANALYSIS OF ANTI-HBS ANTIBODIES PRODUCED IN RESPONSE TO VACCINATION WITH RECOMBINANT HBSAG AND INFECTION WITH THE WILD HEPATITIS B VIRUS,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 25, no. 1-2, pp. 42–49, 2000, [Online]. Available: https://sid.ir/paper/275893/en

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