ROLE OF LOCAL NERVES AND PROSTAGLANDINS IN REGULATION OF BASAL BLOOD FLOW AND
HYPERCAPNIC VASODILATATION OF CEREBRAL BLOOD VESSELS IN THE RABBIT

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NAJAFIPOUR H.; YEGANEH HADJ AHMADI M.; VAKILI A.

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Journal Paper

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Journal: Iranian Journal of Medical Sciences Year:2002 | Volume:27 | Issue:4 Page(s): 188-190

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Title

ROLE OF LOCAL NERVES AND PROSTAGLANDINS IN REGULATION OF BASAL BLOOD FLOW AND HYPERCAPNIC VASODILATATION OF CEREBRAL BLOOD VESSELS IN THE RABBIT

Author(s)

NAJAFIPOUR H. | YEGANEH HADJ AHMADI M. | VAKILI A. | Issue Writer Certificate

Keywords

CEREBRAL BLOOD FLOW • HYPERCAPNIA • NERVES • PROSTAGLANDINS

Abstract

Background: The mechanisms underlying cerebral vasodilatation
during hypercapnia are not fully understood.
Objective: To examine the role of nerves and prostaglandins in the
regulation of basal blood flow and in hypercapnia-induced vasodilatation
in the cerebral blood vessels of rabbit.
Methods: Cerebral blood flow was measured by laser Doppler flowmeter
in 18 NZW rabbits anesthetized with sodium pentobarbital.
Tetrodetoxin was administered locally and indomethacin (a prostaglandin
inhibitor) both locally and systemically before and during
induction of hypercapnia.
Results: Basal cerebral blood flow did not change significantly in
response to local tetrodetoxin, and also after local and systemic administration
of indomethacin. Hypercapnia increased cerebral blood
flow by 25.9±3.9% before and by 24.3±6.5% after administration of
TTX and by 22.1±7.1% before and by 18.2±6.3% after administration
of indomethacin.
Conclusion: In the rabbit, prostaglandin and regional nerves had no
role in regulation of basal cerebral blood flow, nor did they contribute
to cerebral vascular dilatation during hypercapnia.

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APA: Copy

NAJAFIPOUR, H., VAKILI, A., & YEGANEH HADJ AHMADI, M.. (2002). ROLE OF LOCAL NERVES AND PROSTAGLANDINS IN REGULATION OF BASAL BLOOD FLOW AND HYPERCAPNIC VASODILATATION OF CEREBRAL BLOOD VESSELS IN THE RABBIT. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 27(4), 188-190. SID. https://sid.ir/paper/275954/en

Vancouver: Copy

NAJAFIPOUR H., VAKILI A., YEGANEH HADJ AHMADI M.. ROLE OF LOCAL NERVES AND PROSTAGLANDINS IN REGULATION OF BASAL BLOOD FLOW AND HYPERCAPNIC VASODILATATION OF CEREBRAL BLOOD VESSELS IN THE RABBIT. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2002;27(4):188-190. Available from: https://sid.ir/paper/275954/en

IEEE: Copy

H. NAJAFIPOUR, A. VAKILI, and M. YEGANEH HADJ AHMADI, “ROLE OF LOCAL NERVES AND PROSTAGLANDINS IN REGULATION OF BASAL BLOOD FLOW AND HYPERCAPNIC VASODILATATION OF CEREBRAL BLOOD VESSELS IN THE RABBIT,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 27, no. 4, pp. 188–190, 2002, [Online]. Available: https://sid.ir/paper/275954/en

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