IMMEDIATE DIAGNOSIS OF EARLY ONSET SEPSIS IN PREMATURE NEWBORNS BY MEASUREMENT OF CORD C - REACTIVE PROTEIN AND INTERLEUKIN-6

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GHARAH BAGHI M.M.; MAMOURI GH.A.; PEYRAVI FAR A.; BOSKABADI H.; AFSHARI J.T.; SHAKERI M.T.

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Journal Paper

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Journal: Iranian Journal of Medical Sciences Year:2007 | Volume:32 | Issue:4 Page(s): 217-221

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Title

IMMEDIATE DIAGNOSIS OF EARLY ONSET SEPSIS IN PREMATURE NEWBORNS BY MEASUREMENT OF CORD C - REACTIVE PROTEIN AND INTERLEUKIN-6

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Keywords

PREMATURE NEWBORN

SEPSIS

CRP

INTERLEUKIN-6

Abstract

Background: The purpose of this study was to determine the relationship between early onset SEPSIS and increased levels of Creactive protein (CRP) and INTERLEUKIN-6 (IL-6) in cord plasma.Methods: A prospective study was conducted in 141 premature infants delivered with gestational ages of 26-35 weeks.IL-6 and CPR were measured by enzyme-linked immunoassay in the cord plasma of the neonates. According to clinical, laboratory findings and blood culture results, newborn infants were allocated into four groups (A-D): documented early onset infection, clinical SEPSIS, possible infection, and control groups respectively.Results: Mean IL-6 levels in group A-D was 264, 212, 160, and 33.3 pg/ml respectively. Difference between groups was statistically significant (p=.002). With cut off point of 18 pg/ml, the sensitivity and specificity of IL-6 for diagnosis of early onset SEPSIS was 72% and 55% respectively. There was not significant difference between mean levels of CRP among groups (p=0.28).Conclusion: Having considered the relatively good sensitivity and moderate specificity of cord IL-6, using this test can be recommended as a useful detector of early onset SEPSIS and non-infected sick neonates.

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APA: Copy

GHARAH BAGHI, M.M., MAMOURI, GH.A., PEYRAVI FAR, A., BOSKABADI, H., AFSHARI, J.T., & SHAKERI, M.T.. (2007). IMMEDIATE DIAGNOSIS OF EARLY ONSET SEPSIS IN PREMATURE NEWBORNS BY MEASUREMENT OF CORD C - REACTIVE PROTEIN AND INTERLEUKIN-6. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 32(4), 217-221. SID. https://sid.ir/paper/276177/en

Vancouver: Copy

GHARAH BAGHI M.M., MAMOURI GH.A., PEYRAVI FAR A., BOSKABADI H., AFSHARI J.T., SHAKERI M.T.. IMMEDIATE DIAGNOSIS OF EARLY ONSET SEPSIS IN PREMATURE NEWBORNS BY MEASUREMENT OF CORD C - REACTIVE PROTEIN AND INTERLEUKIN-6. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2007;32(4):217-221. Available from: https://sid.ir/paper/276177/en

IEEE: Copy

M.M. GHARAH BAGHI, GH.A. MAMOURI, A. PEYRAVI FAR, H. BOSKABADI, J.T. AFSHARI, and M.T. SHAKERI, “IMMEDIATE DIAGNOSIS OF EARLY ONSET SEPSIS IN PREMATURE NEWBORNS BY MEASUREMENT OF CORD C - REACTIVE PROTEIN AND INTERLEUKIN-6,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 32, no. 4, pp. 217–221, 2007, [Online]. Available: https://sid.ir/paper/276177/en

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