THE EFFICACY OF LAMIVUDINE ALONE, AND IN COMBINATION WITH INTERFERON IN THE TREATMENT OF RESISTAMT CHRONIC HEPATITIS B

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MONTAZERI G.; MALEKZADEH R.; NOURI N.; SOHRABI M.R.; SOTOUDEH M.; KAMALIAN N.; FARHADI M.

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Journal: Iranian Journal of Medical Sciences Year:2001 | Volume:26 | Issue:1-2 Page(s): 1-9

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Title

THE EFFICACY OF LAMIVUDINE ALONE, AND IN COMBINATION WITH INTERFERON IN THE TREATMENT OF RESISTAMT CHRONIC HEPATITIS B

Author(s)

Keywords

CHRONIC HEPATITIS B

LAMIVUDINE

INTERFERON

PRECORE MUTANTS

Abstract

Background/Objective: To evaluate the efficacy of LAMIVUDINE alone and in combination with INTERFERON in patients with CHRONIC HEPATITIS B who were nonresponsive to previous INTERFERON therapy.Methods: Thirty-six adult patients, who were previously nonresponders to INTERFERON, were randomly divided into two groups. Group I received LAMIVUDINE 100mg daily for nine months, and Group II received LAMIVUDINE 100mg daily for nine months in addition to INTERFERON 5-10´106 u three times weekly for 6 months. Patients were followed up for another 6 months without receiving any medication.The end points were; normalization of liver enzymes, sustained negative DNA and reduction of at least 2 points in the necroinfiammatory scores of the liver biopsies on the basis of the modified Knodell HAl system.Results: In Group I, 55.6% had sustained negative DNA (P=0.001). The mean AST value of 75.22±64.14 ull before treatment decreased to 28.28±13.19 u/l after treatment (P=0.01). The mean ALT value of 104.22±92.96 u/l before treatment decreased to 31.22±20.10 u/l after treatment (P=0.005). The histological response was 38.8% (P=0.003). In Group 11, 38.9% had sustained negative viral DNA (0.004). The mean AST value of 67.29±53.07 prior to treatment decreased to 26.88±15.85 u/l after treatment (P=0.008). The mean ALT value of 98.24±75.92 u/l prior to treatment decreased to 28.06±21.53 u/l after treatment (P=0.002). The histological response rate was 27.7% (P=0.004). The P values were not significant comparing the post treatment AST, ALT, sustained negative HBV DNA and histological responses of the two groups.Conclusions: It is concluded that both groups had a relatively good response rate with no statistically significant difference between the two groups. The adverse effect was more prevalent in Group II. It is suggested that CHRONIC HEPATITIS B nonresponders to INTERFERON should be treated with LAMIVUDINE therapy alone.

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APA: Copy

MONTAZERI, G., MALEKZADEH, R., NOURI, N., SOHRABI, M.R., SOTOUDEH, M., KAMALIAN, N., & FARHADI, M.. (2001). THE EFFICACY OF LAMIVUDINE ALONE, AND IN COMBINATION WITH INTERFERON IN THE TREATMENT OF RESISTAMT CHRONIC HEPATITIS B. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 26(1-2), 1-9. SID. https://sid.ir/paper/276217/en

Vancouver: Copy

MONTAZERI G., MALEKZADEH R., NOURI N., SOHRABI M.R., SOTOUDEH M., KAMALIAN N., FARHADI M.. THE EFFICACY OF LAMIVUDINE ALONE, AND IN COMBINATION WITH INTERFERON IN THE TREATMENT OF RESISTAMT CHRONIC HEPATITIS B. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2001;26(1-2):1-9. Available from: https://sid.ir/paper/276217/en

IEEE: Copy

G. MONTAZERI, R. MALEKZADEH, N. NOURI, M.R. SOHRABI, M. SOTOUDEH, N. KAMALIAN, and M. FARHADI, “THE EFFICACY OF LAMIVUDINE ALONE, AND IN COMBINATION WITH INTERFERON IN THE TREATMENT OF RESISTAMT CHRONIC HEPATITIS B,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 26, no. 1-2, pp. 1–9, 2001, [Online]. Available: https://sid.ir/paper/276217/en

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