ANTIBODY RESPONSE TO RECOMBINANT HEPATITIS B SURFACE ANTIGEN IN HEALTHY ADULTS FOLLOWING PRIMARY AND SUPPLEMENTARY VACCINATION

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SHOKRGOZAR M.A.; SHOKRI F.

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Journal: Iranian Journal of Medical Sciences Year:2001 | Volume:26 | Issue:1-2 Page(s): 10-15

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Title

ANTIBODY RESPONSE TO RECOMBINANT HEPATITIS B SURFACE ANTIGEN IN HEALTHY ADULTS FOLLOWING PRIMARY AND SUPPLEMENTARY VACCINATION

Author(s)

SHOKRGOZAR M.A. | SHOKRI F.

Keywords

HEPATITIS B VIRUS

VACCINATION

ANTI-HBS ANTIBODY

Abstract

Background: A proportion of healthy adults and neonates do not respond to VACCINATION with hepatitis B surface antigen (HBsAg ). Re-vaccination induces a protective antibody response in a minor proportion of non-responders.Objective: To study the immunogenicity of primary and secondary VACCINATIONs with recombinant hepatitis B vaccine in healthy adults, and to compare the results with those who obtained the vaccine only in the neonatal period. Methods: Ninety-one healthy adults were immunized with triple doses of recombinant hepatitis B vaccine given at 0, 1 and 6 months intervals. The responder individuals were arbitrarily classified into low and high responders, based on the ANTI-HBS ANTIBODY titer. The non-responder subjects were subsequently re-vaccinated with 2-5 additional doses of the vaccine. ANTI-HBS ANTIBODY and HBs antigen were detected by a sandwich ELISA, and anti-HBc antibody was detected by a competitive ELISA.Results: A protective level of ANTI-HBS ANTIBODY (> 10 lU/L) was developed in 93.4% (85/91) of the vaccinees following primary VACCINATION. Only one of the non-responders (16.6%) seroconverted and developed low titer of anit-HBs antibody after administration of additional 3-5 vaccine doses.Conclusion: Our results suggest that unresponsiveness to HEPATITIS B VIRUS (HBV) may be differentially regulated in adults as compared to neonates.

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APA: Copy

SHOKRGOZAR, M.A., & SHOKRI, F.. (2001). ANTIBODY RESPONSE TO RECOMBINANT HEPATITIS B SURFACE ANTIGEN IN HEALTHY ADULTS FOLLOWING PRIMARY AND SUPPLEMENTARY VACCINATION. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 26(1-2), 10-15. SID. https://sid.ir/paper/276218/en

Vancouver: Copy

SHOKRGOZAR M.A., SHOKRI F.. ANTIBODY RESPONSE TO RECOMBINANT HEPATITIS B SURFACE ANTIGEN IN HEALTHY ADULTS FOLLOWING PRIMARY AND SUPPLEMENTARY VACCINATION. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2001;26(1-2):10-15. Available from: https://sid.ir/paper/276218/en

IEEE: Copy

M.A. SHOKRGOZAR, and F. SHOKRI, “ANTIBODY RESPONSE TO RECOMBINANT HEPATITIS B SURFACE ANTIGEN IN HEALTHY ADULTS FOLLOWING PRIMARY AND SUPPLEMENTARY VACCINATION,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 26, no. 1-2, pp. 10–15, 2001, [Online]. Available: https://sid.ir/paper/276218/en

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