PROTECTIVE EFFECTS OF VITAMIN E AND/OR QUERCETIN CO-SUPPLEMENTATION ON THE MORPHOLOGY OF KIDNEY IN CYCLOSPORINE A-TREATED RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOSTAFAVIPOUR Z.; VESAL M.; ZAL F.; KHOUSHDEL Z.; TORABINEZHAD S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS) Year:2009 | Volume:34 | Issue:4 Page(s): 271-276

Download Full-Text

View:

311

Download:

153

Cites:

Information Journal Paper

Title

PROTECTIVE EFFECTS OF VITAMIN E AND/OR QUERCETIN CO-SUPPLEMENTATION ON THE MORPHOLOGY OF KIDNEY IN CYCLOSPORINE A-TREATED RATS

Author(s)

Keywords

CYCLOSPORINE A

KIDNEY

MORPHOLOGY

VITAMIN E

QUERCETIN

RATS

Abstract

Background: CYCLOSPORINE A (CsA) is a nephrotoxic immunosuppressive drug. Antioxidants might attenuate its toxicity. In the present study, the effects of VITAMIN E and QUERCETIN on the MORPHOLOGY of KIDNEY in CsA-treated RATS were investigated.Methods: Six groups of RATS were used in this gavage feeding study either for 4 or 8 weeks. Groups 1 and 2 received either olive oil or 25% ethanol in olive oil per day. Group 3 received CsA (25 mg/kg/day) in olive oil. All other groups received CsA plus the following: group 4, VITAMIN E (100 mg/kg/day) in olive oil; group 5, QUERCETIN (15 mg/kg/day) in 25% ethanol in olive oil; and group 6, VITAMIN E plus QUERCETIN. In the final day of the study, the animals were sacrificed and KIDNEY sections were prepared for morphologic studies using light microscopy.Results: Acute morphologic alterations induced by CsA in the KIDNEY tubules included isometric vacuolization, brush border loss, microcalcification, and presence of inclusion bodies. Smooth muscle degeneration and necrosis were developed in arterioles. Treatment with VITAMIN E plus QUERCETIN prevented severe, moderate, and mild abnormalities of the tubules. However fibrosis was the only microscopic change of the interstitium that was not present in animals treated with VITAMIN E plus QUERCETIN after both periods. Some mild morphological changes of the blood vessels such as arteriolar medial smooth muscle degeneration and necrosis, arteriolar myocyte dropout and arteriolar wall hyalinization caused by CsA disappeared with administration of VITAMIN E, QUERCETIN or VITAMIN E plus QUERCETIN in both periods.Conclusion: Co-administration of VITAMIN E plus QUERCETIN with CsA in renal transplant patients may be beneficial in reducing the nephrotoxic effects of CsA.

Cites

No record.

References

No record.

Cite

APA: Copy

MOSTAFAVIPOUR, Z., VESAL, M., ZAL, F., KHOUSHDEL, Z., & TORABINEZHAD, S.. (2009). PROTECTIVE EFFECTS OF VITAMIN E AND/OR QUERCETIN CO-SUPPLEMENTATION ON THE MORPHOLOGY OF KIDNEY IN CYCLOSPORINE A-TREATED RATS. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 34(4), 271-276. SID. https://sid.ir/paper/276297/en

Vancouver: Copy

MOSTAFAVIPOUR Z., VESAL M., ZAL F., KHOUSHDEL Z., TORABINEZHAD S.. PROTECTIVE EFFECTS OF VITAMIN E AND/OR QUERCETIN CO-SUPPLEMENTATION ON THE MORPHOLOGY OF KIDNEY IN CYCLOSPORINE A-TREATED RATS. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2009;34(4):271-276. Available from: https://sid.ir/paper/276297/en

IEEE: Copy

Z. MOSTAFAVIPOUR, M. VESAL, F. ZAL, Z. KHOUSHDEL, and S. TORABINEZHAD, “PROTECTIVE EFFECTS OF VITAMIN E AND/OR QUERCETIN CO-SUPPLEMENTATION ON THE MORPHOLOGY OF KIDNEY IN CYCLOSPORINE A-TREATED RATS,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 34, no. 4, pp. 271–276, 2009, [Online]. Available: https://sid.ir/paper/276297/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops