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1

Information Journal Paper

Title

THE ANTIMICROBIAL ACTIVITIES OF EXTRACT AND COMPOUNDS ISOLATED FROM BRILLANTAISIA LAMIUM

Pages

  24-31

Abstract

 Background: Brillantaisia lamium is an erect branched herb, which grows to a height of 1.50 m in moist tropical areas, both in full sun and partial shade. In Cameroon, the aerial part of this plant is used in the treatment of various microbial infections such as skin diseases and infections of urinary tract. The aim of this study was to evaluate the antimicrobial activities of CH2Cl2: MeOH (1: 1) extract, fractions and compounds from the aerial part of B. lamium.Methods: The plant was dried and extracted by maceration in CH2Cl2: MeOH (1: 1 v/v). Structures of the compounds from the CH2Cl2: MeOH (1: 1) soluble fraction were determined by spectroscopic methods and compared with published data. The broth micro dilution method was used to evaluate the antimicrobial activities against bacterial and fungal species.Results: Four known compounds: aurantiamide acetate (1), lupeol (2), lespedin (3), sitosterol 3-O-b-D-glucopyranoside (4) and a mixture of sterols: campesterol (5), stigmasterol (6) and b-sitosterol (7) were isolated from CH2Cl2: MeOH (1: 1) extract of B. lamium aerial parts. The crude extract, fractions and isolated compounds exhibited both ANTIBACTERIAL and ANTIFUNGAL activities that varied with microorganism (MIC=6.25 – 1000 mg/ml). Compound 3 was the most active (MIC=6.25 – 100 mg/ml) while Staphylococcus aureus, Enterococcus faecalis, Candida tropicalis and Cryptococcus neoformans were the most sensitive to all the tested compounds.Conclusion: The overall results of this study indicate that the CH2Cl2: MeOH (1: 1) extract and some of isolated compounds have interesting antimicrobial properties and can be used for the treatment of fungal and bacterial infections.

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    • Cite

    APA: Copy

    DE DIEU TAMOKOU, J., ROGER KUIATE, J., TENE, M., JULBELIN KENLA NWEMEGUELA, T., & TANE, P.. (2011). THE ANTIMICROBIAL ACTIVITIES OF EXTRACT AND COMPOUNDS ISOLATED FROM BRILLANTAISIA LAMIUM. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 36(1), 24-31. SID. https://sid.ir/paper/276373/en

    Vancouver: Copy

    DE DIEU TAMOKOU J., ROGER KUIATE J., TENE M., JULBELIN KENLA NWEMEGUELA T., TANE P.. THE ANTIMICROBIAL ACTIVITIES OF EXTRACT AND COMPOUNDS ISOLATED FROM BRILLANTAISIA LAMIUM. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2011;36(1):24-31. Available from: https://sid.ir/paper/276373/en

    IEEE: Copy

    J. DE DIEU TAMOKOU, J. ROGER KUIATE, M. TENE, T. JULBELIN KENLA NWEMEGUELA, and P. TANE, “THE ANTIMICROBIAL ACTIVITIES OF EXTRACT AND COMPOUNDS ISOLATED FROM BRILLANTAISIA LAMIUM,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 36, no. 1, pp. 24–31, 2011, [Online]. Available: https://sid.ir/paper/276373/en

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