SERUM LEVEL OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN PATIENTS WITH DIFFERENT CLINICAL SUBTYPES OF ORAL LICHEN PLANUS

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MARDANI MARYAM; GHABANCHI JANNAN; FATTAHI MOHAMMAD JAVAD; ANDISHEH TADBIR AZADEH

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Paper Information

Journal: IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS) Year:2012 | Volume:37 | Issue:4 Page(s): 233-237

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Title

SERUM LEVEL OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN PATIENTS WITH DIFFERENT CLINICAL SUBTYPES OF ORAL LICHEN PLANUS

Author(s)

MARDANI MARYAM | GHABANCHI JANNAN | FATTAHI MOHAMMAD JAVAD | ANDISHEH TADBIR AZADEH | Issue Writer Certificate

Keywords

ORAL LICHEN PLANUS

VASCULAR ENDOTHELIAL GROWTH FACTOR

SERUM

Abstract

Background: ORAL LICHEN PLANUS is a chronic inflammatory disease with a poorly understood etiology. The role of angiogenesis in the development of different chronic inflammatory diseases is of great concern. VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) is an important regulator of angiogenesis. We aimed to evaluate the SERUM level of VEGF in patients with ORAL LICHEN PLANUS compared with normal individuals and consider its clinical significance.Methods: In this case-control study, 36 SERUM samples from patients diagnosed with ORAL LICHEN PLANUS admitted to the Oral Medicine Department of the School of Dentistry at Shiraz University of Medical Sciences (14 men, 22 women, mean [±SD] age: 38.8 [±6.07] years) and 23 SERUM samples from healthy individuals (9 men, 14 women, mean [±SD] age: 38.7 [±4.9] years) were collected. VEGF concentration was measured using the ELISA method. The Mann-Whitney test was used for statistical analysis.Results: The SERUM VEGF level was significantly higher in patients with ORAL LICHEN PLANUS compared with the healthy controls (112.97 [±63.2] vs.66.21 [±56.2] ngr/ml, P<0.001). A similar difference was also observed between the two types of ORAL LICHEN PLANUS, being more pronounced in the erosive form (P<0.001).Conclusion: SERUM VEGF can be used as a useful and suitable marker to scrutinize the disease activity.

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APA: Copy

MARDANI, MARYAM, GHABANCHI, JANNAN, FATTAHI, MOHAMMAD JAVAD, & ANDISHEH TADBIR, AZADEH. (2012). SERUM LEVEL OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN PATIENTS WITH DIFFERENT CLINICAL SUBTYPES OF ORAL LICHEN PLANUS. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 37(4), 233-237. SID. https://sid.ir/paper/276469/en

Vancouver: Copy

MARDANI MARYAM, GHABANCHI JANNAN, FATTAHI MOHAMMAD JAVAD, ANDISHEH TADBIR AZADEH. SERUM LEVEL OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN PATIENTS WITH DIFFERENT CLINICAL SUBTYPES OF ORAL LICHEN PLANUS. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2012;37(4):233-237. Available from: https://sid.ir/paper/276469/en

IEEE: Copy

MARYAM MARDANI, JANNAN GHABANCHI, MOHAMMAD JAVAD FATTAHI, and AZADEH ANDISHEH TADBIR, “SERUM LEVEL OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN PATIENTS WITH DIFFERENT CLINICAL SUBTYPES OF ORAL LICHEN PLANUS,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 37, no. 4, pp. 233–237, 2012, [Online]. Available: https://sid.ir/paper/276469/en

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