EFFECT OF GABAA RECEPTORS IN THE ROSTRAL VENTROLATERAL MEDULLA ON CARDIOVASCULAR RESPONSE TO THE ACTIVATION OF THE BED NUCLEUS OF THE STRIA TERMINALIS IN FEMALE OVARIECTOMIZED RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HATAM MASOUMEH; GANJKHANI MAHIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS) Year:2012 | Volume:37 | Issue:4 Page(s): 242-252

Download Full-Text

View:

209

Download:

Cites:

Information Journal Paper

Title

EFFECT OF GABAA RECEPTORS IN THE ROSTRAL VENTROLATERAL MEDULLA ON CARDIOVASCULAR RESPONSE TO THE ACTIVATION OF THE BED NUCLEUS OF THE STRIA TERMINALIS IN FEMALE OVARIECTOMIZED RATS

Author(s)

HATAM MASOUMEH | GANJKHANI MAHIN | Issue Writer Certificate

Keywords

BED NUCLEUS OF THE STRIA TERMINALIS

GAMMAAMINOBUTYRIC ACID

ESTROGEN

Abstract

Background: The areas of the BED NUCLEUS OF THE STRIA TERMINALIS (BST) with a high density of ESTROGEN receptors are involved in cardiovascular regulation and send axonal projections to the rostroventrolateral medulla (RVLM). We aimed to find the contribution of the RVLM to cardiovascular responses elicited by glutamate microinjection into the BST.Methods: Experiments were done in a-chloralose anesthetized ovariectomized (OVX) or OVX ESTROGEN treated (OVX+E) female Wistar rats. Drugs were microinjected into the BST and RVLM. The average changes in mean arterial pressure (MAP) and heart rate (HR) were compared between the case and control groups usingt test and with the pre-injection values using paired t test.Results: Unilateral microinjection of glutamate (0.25 M/50 nl) into the BST decreased MAP and HR, in the OVX+E and OVX rats. These cardiovascular responses were reversibly attenuated 10 minutes after microinjection of synaptic blocker cobalt chloride (CoCl2, 5 mM/50 nl) into the ipsilateral RVLM. Re-stimulation of the BST 60 min after CoCl2 injection elicited cardiovascular responses that were not different from the control values. Ipsilateral microinjection of GABAA antagonist bicuculline (1.0 mM/50 nl) into the RVLM caused a 50% attenuation of glutamate induced depressor and bradycardic responses in both groups. Ipsilateral microinjection of GABAB antagonist, phaclophen (5.0 mM/50 nl), into the RVLM did not affect the depressor and bradycardic responses due to re-stimulation of the BST by glutamate.Conclusion: The RVLM sympathetic premotor neurons contain GABAA receptors that mediate in part the sympathoinhibitory responses to stimulation of the BST in the OVX animals.

Cites

No record.

References

No record.

Cite

APA: Copy

HATAM, MASOUMEH, & GANJKHANI, MAHIN. (2012). EFFECT OF GABA_A RECEPTORS IN THE ROSTRAL VENTROLATERAL MEDULLA ON CARDIOVASCULAR RESPONSE TO THE ACTIVATION OF THE BED NUCLEUS OF THE STRIA TERMINALIS IN FEMALE OVARIECTOMIZED RATS. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 37(4), 242-252. SID. https://sid.ir/paper/276472/en

Vancouver: Copy

HATAM MASOUMEH, GANJKHANI MAHIN. EFFECT OF GABA_A RECEPTORS IN THE ROSTRAL VENTROLATERAL MEDULLA ON CARDIOVASCULAR RESPONSE TO THE ACTIVATION OF THE BED NUCLEUS OF THE STRIA TERMINALIS IN FEMALE OVARIECTOMIZED RATS. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2012;37(4):242-252. Available from: https://sid.ir/paper/276472/en

IEEE: Copy

MASOUMEH HATAM, and MAHIN GANJKHANI, “EFFECT OF GABA_A RECEPTORS IN THE ROSTRAL VENTROLATERAL MEDULLA ON CARDIOVASCULAR RESPONSE TO THE ACTIVATION OF THE BED NUCLEUS OF THE STRIA TERMINALIS IN FEMALE OVARIECTOMIZED RATS,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 37, no. 4, pp. 242–252, 2012, [Online]. Available: https://sid.ir/paper/276472/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops