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Information Journal Paper

Title

CARDIOPROTECTIVE EFFECT OF EXTENDED REMOTE ISCHEMIC PRECONDITIONING IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFTING: A RANDOMIZED CLINICAL TRIAL

Pages

  265-274

Abstract

 Background: The cardioprotective effect of ISCHEMIC PRECONDITIONING has been known for many years. Since the temporary ischemia in the heart may cause lethal cardiac effects, the idea of creating ischemia in organs far from the heart such as limbs was raised as remote ISCHEMIC PRECONDITIONING (RIPC). We hypothesized that the extension of RIPC has more cardioprotective effect in patients undergoing CORONARY ARTERY BYPASS graft (CABG) surgeries.Methods: In this triple-blind randomized clinical trial study, 96 patients were randomly divided into 3 groups and two blood pressure cuffs were placed on both upper and lower extremities.In group A, only upper extremity cuff and in group B upper limb and lower limb cuff was inflated intermittently and group C was the control group. RIPC was induced with three 5-min cycles of cuff inflation about 100 mmHg over the initial systolic blood pressure before starting cardiopulmonary bypass. The primary endpoints were TROPONIN I and creatine phosphokinasemyoglobin isoenzyme (CK-MB).Results: Six hours after the termination of CPB, there was a peak release of the TROPONIN I level in all groups (group A=4.90 ng/ml, group B=4.40 ng/ml, and group C=4.50 ng/ml). There was a rise in plasma CK-MB in all groups postoperatively and there were not any significant differences in TROPONIN I and CK-MB release between the three groups.Conclusion: RIPC induced by upper and lower limb ischemia does not reduce postoperative myocardial enzyme elevation in adult patients undergoing CABG.

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    APA: Copy

    KARAMI, ALI, KHOSRAVI, MOHAMMAD BAGHER, SHAFA, MASIH, AZEMATI, SIMIN, KHADEMI, SAEED, AKHLAGH, SEYED HEDAYATALLA, & MAGHSOUDI, BEHZAD. (2016). CARDIOPROTECTIVE EFFECT OF EXTENDED REMOTE ISCHEMIC PRECONDITIONING IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFTING: A RANDOMIZED CLINICAL TRIAL. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 41(4), 265-274. SID. https://sid.ir/paper/276544/en

    Vancouver: Copy

    KARAMI ALI, KHOSRAVI MOHAMMAD BAGHER, SHAFA MASIH, AZEMATI SIMIN, KHADEMI SAEED, AKHLAGH SEYED HEDAYATALLA, MAGHSOUDI BEHZAD. CARDIOPROTECTIVE EFFECT OF EXTENDED REMOTE ISCHEMIC PRECONDITIONING IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFTING: A RANDOMIZED CLINICAL TRIAL. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2016;41(4):265-274. Available from: https://sid.ir/paper/276544/en

    IEEE: Copy

    ALI KARAMI, MOHAMMAD BAGHER KHOSRAVI, MASIH SHAFA, SIMIN AZEMATI, SAEED KHADEMI, SEYED HEDAYATALLA AKHLAGH, and BEHZAD MAGHSOUDI, “CARDIOPROTECTIVE EFFECT OF EXTENDED REMOTE ISCHEMIC PRECONDITIONING IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFTING: A RANDOMIZED CLINICAL TRIAL,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 41, no. 4, pp. 265–274, 2016, [Online]. Available: https://sid.ir/paper/276544/en

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