TIME COURSE OF DEGRADATION AND DEADENYLATION OF MATERNAL C-MOS AND CYCLIN A2 MRNA DURING EARLY DEVELOPMENT OF ONE-CELL EMBRYO IN MOUSE

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ALIZADEH Z.; PASBAKHSH P.; SOBHANI A.; BARBARESTANI M.; GHAFARI M.; ETESAM F.

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Journal: Iranian Biomedical Journal Year:2004 | Volume:8 | Issue:4 Page(s): 179-183

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Title

TIME COURSE OF DEGRADATION AND DEADENYLATION OF MATERNAL C-MOS AND CYCLIN A2 MRNA DURING EARLY DEVELOPMENT OF ONE-CELL EMBRYO IN MOUSE

Author(s)

Keywords

MATERNAL MRNA

MOUSE EMBRYO

MRNA DEGRADATION

C-MOS

CYCLIN A2

Abstract

Early in the development of many animals, before transcription begins, any change in the pattern of protein synthesis is attributed to a change in the translational activity or stability of mRNA in the egg and early embryo. As a result, translational control is critical for a variety of developmental decisions, including oocyte maturation and initiation of preimplantation development. In this study, using real-time RT-PCR method, we defined the time course of degradation and deadenylation of an oocyte specific gene (c-mos) more precisely and a gene that is re-synthesized after ZGA (cyclin A2). Our data indicate that oocyte-specific transcript, C-MOS, degrades rapidly while CYCLIN A2 mRNA does not and the deadenylation of C-MOS mRNA precedes the process of degradation. Our findings suggest that time-dependent elimination of different MATERNAL MRNA is a way for regulation of translation in early development of MOUSE EMBRYOs.

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APA: Copy

ALIZADEH, Z., PASBAKHSH, P., SOBHANI, A., BARBARESTANI, M., GHAFARI, M., & ETESAM, F.. (2004). TIME COURSE OF DEGRADATION AND DEADENYLATION OF MATERNAL C-MOS AND CYCLIN A2 MRNA DURING EARLY DEVELOPMENT OF ONE-CELL EMBRYO IN MOUSE. IRANIAN BIOMEDICAL JOURNAL, 8(4), 179-183. SID. https://sid.ir/paper/276977/en

Vancouver: Copy

ALIZADEH Z., PASBAKHSH P., SOBHANI A., BARBARESTANI M., GHAFARI M., ETESAM F.. TIME COURSE OF DEGRADATION AND DEADENYLATION OF MATERNAL C-MOS AND CYCLIN A2 MRNA DURING EARLY DEVELOPMENT OF ONE-CELL EMBRYO IN MOUSE. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2004;8(4):179-183. Available from: https://sid.ir/paper/276977/en

IEEE: Copy

Z. ALIZADEH, P. PASBAKHSH, A. SOBHANI, M. BARBARESTANI, M. GHAFARI, and F. ETESAM, “TIME COURSE OF DEGRADATION AND DEADENYLATION OF MATERNAL C-MOS AND CYCLIN A2 MRNA DURING EARLY DEVELOPMENT OF ONE-CELL EMBRYO IN MOUSE,” IRANIAN BIOMEDICAL JOURNAL, vol. 8, no. 4, pp. 179–183, 2004, [Online]. Available: https://sid.ir/paper/276977/en

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