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Information Journal Paper

Title

EFFECT OF AQUEOUS GARLIC (ALLIUM SATIVUM L.) EXTRACT ON ACETYLCHOLINE AND ISOSORBIDE-INDUCED RELAXATION OF ISOLATED AORTA IN RAT

Author(s)

 HOMAYOUN FAR HOMAYOUN | BALUCHNEJADMOJARAD TOURANDOKHT | ROUGHANI M. | HOSSEINI M. | KAMALINEZHAD M. | Issue Writer Certificate 

Pages

  23-27

Abstract

 The hypotensive effect of garlic has been well-documented in human subjects and animals. Since endothelial activity regulates vascular reactivity in physiological and pathophysiological conditions, the aim of the present study was to investigate the effect of garlic on endothelium-dependent and independent relaxation of rat aorta for elucidation of mechanism of the garlic anti-hypertensive effect. Four and eight weeks after treatment with garlic extract, AORTIC RINGS were studied for relaxation response to ACETYLCHOLINE and ISOSORBIDE DINITRATE. The obtained results showed that endothelium-dependent relaxation response of AORTIC RINGS to ACETYLCHOLINE, from rats treated with garlic for 4 and 8 weeks, increases about 5-24% and 3-27%, respectively compared to controls. But, endothelium-independent relaxation response to isosorbide showed no difference in all groups. Moreover, the relaxant effect of garlic extract was time-dependent. The obtained findings strongly suggest that garlic exerts its relaxant effect through endothelium by production and/or releasing of endothelium-derived relaxing factor.

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    APA: Copy

    HOMAYOUN FAR, HOMAYOUN, BALUCHNEJADMOJARAD, TOURANDOKHT, ROUGHANI, M., HOSSEINI, M., & KAMALINEZHAD, M.. (2003). EFFECT OF AQUEOUS GARLIC (ALLIUM SATIVUM L.) EXTRACT ON ACETYLCHOLINE AND ISOSORBIDE-INDUCED RELAXATION OF ISOLATED AORTA IN RAT. IRANIAN BIOMEDICAL JOURNAL, 7(1), 23-27. SID. https://sid.ir/paper/276986/en

    Vancouver: Copy

    HOMAYOUN FAR HOMAYOUN, BALUCHNEJADMOJARAD TOURANDOKHT, ROUGHANI M., HOSSEINI M., KAMALINEZHAD M.. EFFECT OF AQUEOUS GARLIC (ALLIUM SATIVUM L.) EXTRACT ON ACETYLCHOLINE AND ISOSORBIDE-INDUCED RELAXATION OF ISOLATED AORTA IN RAT. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2003;7(1):23-27. Available from: https://sid.ir/paper/276986/en

    IEEE: Copy

    HOMAYOUN HOMAYOUN FAR, TOURANDOKHT BALUCHNEJADMOJARAD, M. ROUGHANI, M. HOSSEINI, and M. KAMALINEZHAD, “EFFECT OF AQUEOUS GARLIC (ALLIUM SATIVUM L.) EXTRACT ON ACETYLCHOLINE AND ISOSORBIDE-INDUCED RELAXATION OF ISOLATED AORTA IN RAT,” IRANIAN BIOMEDICAL JOURNAL, vol. 7, no. 1, pp. 23–27, 2003, [Online]. Available: https://sid.ir/paper/276986/en

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