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Information Journal Paper

Title

SCREENING OF LOVASTATIN PRODUCTION BY FILAMENTOUS FUNGI

Pages

  29-33

Abstract

 In the present study, 110 FUNGAL STRAINS of Persian Type Culture Collection (PTCC) including some selected strains isolated in various SCREENING projects were tested for their potentiality to produce LOVASTATIN, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reduc-tase), the rate-limiting enzyme of cholesterol biosynthesis. The FUNGAL STRAINS were cultivated in a two-stage submerged fermentation followed by SCREENING by TLC. All positive results were evaluated by confirmatory HPLC. Nine species of four genera were found to be LOVASTATIN producers. ASPERGILLUS TERREUS was the best LOVASTATIN producing strain with a level of 55 mg LOVASTATIN per liter of SCREENING production medium

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    APA: Copy

    M.SAMIEE, S., MOAZAMI, N., HAGHIGHI, S., AZIZ MOHSENI, F., MIRDAMADI, S., & BAKHTIARI, M.R.. (2003). SCREENING OF LOVASTATIN PRODUCTION BY FILAMENTOUS FUNGI. IRANIAN BIOMEDICAL JOURNAL, 7(1), 29-33. SID. https://sid.ir/paper/276990/en

    Vancouver: Copy

    M.SAMIEE S., MOAZAMI N., HAGHIGHI S., AZIZ MOHSENI F., MIRDAMADI S., BAKHTIARI M.R.. SCREENING OF LOVASTATIN PRODUCTION BY FILAMENTOUS FUNGI. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2003;7(1):29-33. Available from: https://sid.ir/paper/276990/en

    IEEE: Copy

    S. M.SAMIEE, N. MOAZAMI, S. HAGHIGHI, F. AZIZ MOHSENI, S. MIRDAMADI, and M.R. BAKHTIARI, “SCREENING OF LOVASTATIN PRODUCTION BY FILAMENTOUS FUNGI,” IRANIAN BIOMEDICAL JOURNAL, vol. 7, no. 1, pp. 29–33, 2003, [Online]. Available: https://sid.ir/paper/276990/en

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