مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

PREVENTION OF EXPERIMENTAL AUTOIMMUNE VITILIGO BY ORAL ADMINISTRATION OF MUSHROOM TYROSINASE

Pages

  31-36

Abstract

 Experimental autoimmune vitiligo was induced by the intradermal injection of the purified MUSHROOM TYROSINASE emulsified in Complete Freund’s Adjuvant (CFA) in female C57BL/6 mice. The onset of vitiligo was characterized by hair hypopigmentation and total melanocyte depletion in the basal layer of the epidermis. Oral administration of semipurified MUSHROOM TYROSINASE prevented EXPERIMENTAL AUTOIMMUNE VITILIGO (EAV). Suppression of clinical and histological disease was observed when animals received MUSHROOM TYROSINASE. A decrease in lymphocyte proliferation, delayed type hypersensitivity responses, increase in humoral immunity of the mice may all suggest that the suppression of the disease is correlated with cellular immune responses suppression. Based on our data, it may be concluded that the oral administration of the MUSHROOM TYROSINASE may have practical implications in vitiligo

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    • Cite

    APA: Copy

    ZEHTAB, T., YAZDAN PARAST, R., & RAFIEE, SH.. (2000). PREVENTION OF EXPERIMENTAL AUTOIMMUNE VITILIGO BY ORAL ADMINISTRATION OF MUSHROOM TYROSINASE. IRANIAN BIOMEDICAL JOURNAL, 4(1), 31-36. SID. https://sid.ir/paper/277025/en

    Vancouver: Copy

    ZEHTAB T., YAZDAN PARAST R., RAFIEE SH.. PREVENTION OF EXPERIMENTAL AUTOIMMUNE VITILIGO BY ORAL ADMINISTRATION OF MUSHROOM TYROSINASE. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2000;4(1):31-36. Available from: https://sid.ir/paper/277025/en

    IEEE: Copy

    T. ZEHTAB, R. YAZDAN PARAST, and SH. RAFIEE, “PREVENTION OF EXPERIMENTAL AUTOIMMUNE VITILIGO BY ORAL ADMINISTRATION OF MUSHROOM TYROSINASE,” IRANIAN BIOMEDICAL JOURNAL, vol. 4, no. 1, pp. 31–36, 2000, [Online]. Available: https://sid.ir/paper/277025/en

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