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Information Journal Paper

Title

EFFECTS OF CITALOPRAM ON LEARNING AND MEMORY IN THE MOUSE AND RAT

Pages

  21-29

Abstract

 Data on the effects of SEROTONIN reuptake inhibitors on learning and memory processes are not consistent. In the present study, the effects of CITALOPRAM, a very potent and completely selective inhibitor of the SEROTONIN reuptake on spatial discrimination in the T-maze and Morris water maze, were assessed in mice and/or rats. Animals received different doses of CITALOPRAM (1, 2, 4, 8 or 16 mg/kg, i.p.) or its vehicle (saline) 30 min before training each day. The results showed no significant effects of CITALOPRAM on T-maze discrimination task in mice and rats. However, there was dose-dependent increases in latencies to find the invisible platform and traveled distances in CITALOPRAM received groups compared to the control group with the peak effect at doses of 4 and 8 mg/kg in Morris task. Therefore, it appears that CITALOPRAM can cause learning deficits in complex spatial tasks. Iran. Biomed.

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  • Cite

    APA: Copy

    NAGHDI, N., & MAJLESSI, N.. (2000). EFFECTS OF CITALOPRAM ON LEARNING AND MEMORY IN THE MOUSE AND RAT . IRANIAN BIOMEDICAL JOURNAL, 4(1), 21-29. SID. https://sid.ir/paper/277031/en

    Vancouver: Copy

    NAGHDI N., MAJLESSI N.. EFFECTS OF CITALOPRAM ON LEARNING AND MEMORY IN THE MOUSE AND RAT . IRANIAN BIOMEDICAL JOURNAL[Internet]. 2000;4(1):21-29. Available from: https://sid.ir/paper/277031/en

    IEEE: Copy

    N. NAGHDI, and N. MAJLESSI, “EFFECTS OF CITALOPRAM ON LEARNING AND MEMORY IN THE MOUSE AND RAT ,” IRANIAN BIOMEDICAL JOURNAL, vol. 4, no. 1, pp. 21–29, 2000, [Online]. Available: https://sid.ir/paper/277031/en

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