QUINAPRIL ATTENUATES THE EFFECT OF LONG-TERM L-NAME ADMINISTRATION ON THE VASCULAR REACTIVITY OF DIABETIC RATS

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ROUGHANI DEHKORDI F.; ROUGHANI M.; BALUCHNEJADMOJARAD TOURANDOKHT

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Biomedical Journal Year:2005 | Volume:9 | Issue:1 Page(s): 33-36

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Title

QUINAPRIL ATTENUATES THE EFFECT OF LONG-TERM L-NAME ADMINISTRATION ON THE VASCULAR REACTIVITY OF DIABETIC RATS

Author(s)

ROUGHANI DEHKORDI F. | ROUGHANI M. | BALUCHNEJADMOJARAD TOURANDOKHT | Issue Writer Certificate

Keywords

QUINAPRIL

NITRIC OXIDE

AORTIC REACTIVITY

DIABETES MELLITUS

STREPTOZOTOCIN (STZ)

Abstract

Angiotensin-converting enzyme (ACE) inhibitors including QUINAPRIL could exert a protective effect on cardiovascular system through endothelial system in normoglycemic and diabetic rats. The present experimental work was designed to study the vascular reactivity of aortic ring segments isolated from streptozotocin (STZ)-diabetic rats treated for 4 weeks with nitro-L-arginine-methyl ester (L-NAME; 50 mg/100 ml) or L-NAME plus QUINAPRIL (10 mg/100 ml) in drinking water. The results showed that QUINAPRIL treatment significantly attenuated the augmented contractile response to phenylephrine and KCl in diabetic rats. In addition, QUINAPRIL treatment partially restored the reduced contractile response in diabetic animals treated chronically with L-NAME. It can be concluded that QUINAPRIL could partly counteract the effect of long-term L-NAME administration on vascular reactivity in STZ-diabetic rats.

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APA: Copy

ROUGHANI DEHKORDI, F., ROUGHANI, M., & BALUCHNEJADMOJARAD, TOURANDOKHT. (2005). QUINAPRIL ATTENUATES THE EFFECT OF LONG-TERM L-NAME ADMINISTRATION ON THE VASCULAR REACTIVITY OF DIABETIC RATS. IRANIAN BIOMEDICAL JOURNAL, 9(1), 33-36. SID. https://sid.ir/paper/277085/en

Vancouver: Copy

ROUGHANI DEHKORDI F., ROUGHANI M., BALUCHNEJADMOJARAD TOURANDOKHT. QUINAPRIL ATTENUATES THE EFFECT OF LONG-TERM L-NAME ADMINISTRATION ON THE VASCULAR REACTIVITY OF DIABETIC RATS. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2005;9(1):33-36. Available from: https://sid.ir/paper/277085/en

IEEE: Copy

F. ROUGHANI DEHKORDI, M. ROUGHANI, and TOURANDOKHT BALUCHNEJADMOJARAD, “QUINAPRIL ATTENUATES THE EFFECT OF LONG-TERM L-NAME ADMINISTRATION ON THE VASCULAR REACTIVITY OF DIABETIC RATS,” IRANIAN BIOMEDICAL JOURNAL, vol. 9, no. 1, pp. 33–36, 2005, [Online]. Available: https://sid.ir/paper/277085/en

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