STUDY OF CORRELATION BETWEEN PROSTATE SPECIFIC ANTIGEN AND MATRIX METALLOPROTEINASE-2 ACTIVITY IN BENIGN AND MALIGNANT PROSTATE HYPERPLASIA

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ALIZADEH N.; SAFA O.; KHORAMIZADEH MOHAMMAD REZA; PEZESHKI M.

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Journal: Iranian Biomedical Journal Year:2006 | Volume:10 | Issue:1 Page(s): 27-32

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Title

STUDY OF CORRELATION BETWEEN PROSTATE SPECIFIC ANTIGEN AND MATRIX METALLOPROTEINASE-2 ACTIVITY IN BENIGN AND MALIGNANT PROSTATE HYPERPLASIA

Author(s)

ALIZADEH N. | SAFA O. | KHORAMIZADEH MOHAMMAD REZA | PEZESHKI M. | Issue Writer Certificate

Keywords

MATRIX METALLOPROTEINASE-2 (MMP-2)

PROSTATE HYPERPLASIA

PROSTATE SPECIFIC ANTIGEN (PSA)

ZYMOGRAPHY

Abstract

There are emerging data on novel tumor markers such as matrix metalloproteinase-2 (MMP-2 or gelatinase-A), which play a key role in tissue invasion and metastasis. We designed an investigation to assess the usefulness of MMP-2 activity as compared to prostate specific antigen (PSA) in cancer staging process. We have analyzed the circulating form of MMP-2 in serum samples of patients suffering from either benign PROSTATE HYPERPLASIA (BPH, n = 54) or prostate cancer (PC, n = 26), and prostatitis (n = 4) as compared to control normal individual (n = 26), respectively. Protein-content adjusted samples were separated by gelatin-embedded polyacrylamide gel electrophoresis then were subjected to densitometric analysis. Total PSA (tPSA) and free PSA (fPSA) were quantified using a standard ELISA technique. Correlation coefficient (r) between tPSA and MMP-2 activity in patient group was +0.938 and in controls group was 0.799 (P<0.01). In addition, (r) between tPSA and MMP-2 activity in PC patients was 0.940 and in BPH patients was 0.962 (P<0.01). (r) between fPSA and MMP- 2 activity in PC patients was 0.913, in BPH patients was 0.644, and in prostatitis patients was -0.994 (P<0.01). These results demonstrate that MMP-2, compared to PSA, might be considered as a better tumor marker in monitoring and screening patients with PC.

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APA: Copy

ALIZADEH, N., SAFA, O., KHORAMIZADEH, MOHAMMAD REZA, & PEZESHKI, M.. (2006). STUDY OF CORRELATION BETWEEN PROSTATE SPECIFIC ANTIGEN AND MATRIX METALLOPROTEINASE-2 ACTIVITY IN BENIGN AND MALIGNANT PROSTATE HYPERPLASIA. IRANIAN BIOMEDICAL JOURNAL, 10(1), 27-32. SID. https://sid.ir/paper/277088/en

Vancouver: Copy

ALIZADEH N., SAFA O., KHORAMIZADEH MOHAMMAD REZA, PEZESHKI M.. STUDY OF CORRELATION BETWEEN PROSTATE SPECIFIC ANTIGEN AND MATRIX METALLOPROTEINASE-2 ACTIVITY IN BENIGN AND MALIGNANT PROSTATE HYPERPLASIA. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2006;10(1):27-32. Available from: https://sid.ir/paper/277088/en

IEEE: Copy

N. ALIZADEH, O. SAFA, MOHAMMAD REZA KHORAMIZADEH, and M. PEZESHKI, “STUDY OF CORRELATION BETWEEN PROSTATE SPECIFIC ANTIGEN AND MATRIX METALLOPROTEINASE-2 ACTIVITY IN BENIGN AND MALIGNANT PROSTATE HYPERPLASIA,” IRANIAN BIOMEDICAL JOURNAL, vol. 10, no. 1, pp. 27–32, 2006, [Online]. Available: https://sid.ir/paper/277088/en

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