DIFFERENTIAL EXPRESSION OF RHEUMATOID FACTOR-ASSOCIATED CROSS- REACTIVE IDIOTYPES IN IRANIAN SEROPOSITIVE AND SERONEGATIVE PATIENTS WITH RHEUMATOID ARTHRITIS

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MOSAYEBI GHASEM; GHARAGOUZLOU S.; SHOKRI F.; RIZGAR A. M.

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Journal: Iranian Biomedical Journal Year:2007 | Volume:11 | Issue:1 Page(s): 7-13

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Title

DIFFERENTIAL EXPRESSION OF RHEUMATOID FACTOR-ASSOCIATED CROSS- REACTIVE IDIOTYPES IN IRANIAN SEROPOSITIVE AND SERONEGATIVE PATIENTS WITH RHEUMATOID ARTHRITIS

Author(s)

MOSAYEBI GHASEM | GHARAGOUZLOU S. | SHOKRI F. | RIZGAR A. M. | Issue Writer Certificate

Keywords

RHEUMATOID ARTHRITIS (RA)

RHEUMATOID FACTOR (RF)

CROSS-REACTIVE IDIOTYPES (CRI)

SERONEGATIVE (SN)

SEROPOSITIVE (SP)

Abstract

Introduction: High levels of rheumatoid factors (RF) are detectable in serum of the majority of patients with rheumatoid arthritis (RA), but 5-10% of patients remain seronegative (SN). Despite clinical and genetic similarities between these two subsets of RA, it has been proposed that they may be regarded as distinct clinical entities. Methods: In the present study a panel of monoclonal antibodies (mAb) recognizing RFassociated cross-reactive idiotypes (CRI) linked to the VH1 (G8), VH4 (LC1), VK3b (17-109) and a mAb recognizing the VK3 subgroup (C7) of immunoglobulin variable region (IgV) gene products were used to quantitate the level of expression of these gene products in serum and synovial fluid of 35 seropositive (SP) and 8 SN RA patients by capture ELISA. Results: While the concentration and relative proportion of the IgV are recognized by the mAb G8, 17-109 and C7 were significantly higher in serum and synovial fluid of the SP RA, compared to the SN-RA patients (G8, p = 0.009; 17-109, p = 0.0001; C7, p = 0.001). The CRI recognized by the mAb LC1 was highly represented in serum and synovial fluid of the SN-RA patients. There have been no significant differences in the level of expression of these IgV gene products (other than the product recognized by C7 mAb in SP patients) between serum and synovial fluid of either group of patients. Conclusion: Our results suggest that the expressed repertoire of Ig VH and VK genes in these two subsets of RA is differentially regulated and may be influenced by selective mechanisms leading to positive or negative selection of certain genes.

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APA: Copy

MOSAYEBI, GHASEM, GHARAGOUZLOU, S., SHOKRI, F., & RIZGAR A., M.. (2007). DIFFERENTIAL EXPRESSION OF RHEUMATOID FACTOR-ASSOCIATED CROSS- REACTIVE IDIOTYPES IN IRANIAN SEROPOSITIVE AND SERONEGATIVE PATIENTS WITH RHEUMATOID ARTHRITIS. IRANIAN BIOMEDICAL JOURNAL, 11(1), 7-13. SID. https://sid.ir/paper/277130/en

Vancouver: Copy

MOSAYEBI GHASEM, GHARAGOUZLOU S., SHOKRI F., RIZGAR A. M.. DIFFERENTIAL EXPRESSION OF RHEUMATOID FACTOR-ASSOCIATED CROSS- REACTIVE IDIOTYPES IN IRANIAN SEROPOSITIVE AND SERONEGATIVE PATIENTS WITH RHEUMATOID ARTHRITIS. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2007;11(1):7-13. Available from: https://sid.ir/paper/277130/en

IEEE: Copy

GHASEM MOSAYEBI, S. GHARAGOUZLOU, F. SHOKRI, and M. RIZGAR A., “DIFFERENTIAL EXPRESSION OF RHEUMATOID FACTOR-ASSOCIATED CROSS- REACTIVE IDIOTYPES IN IRANIAN SEROPOSITIVE AND SERONEGATIVE PATIENTS WITH RHEUMATOID ARTHRITIS,” IRANIAN BIOMEDICAL JOURNAL, vol. 11, no. 1, pp. 7–13, 2007, [Online]. Available: https://sid.ir/paper/277130/en

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