DEPLETION OF SEROTONIN SYNTHESIS WITH P-CPA PRETREATMENT ALTERS EEG IN URETHANE ANESTHETIZED RATS UNDER WHOLE BODY HYPERTHERMIA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SINHA R.K.; AGGARWAL Y.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Biomedical Journal Year:2007 | Volume:11 | Issue:1 Page(s): 33-39

Download Full-Text

View:

384

Download:

202

Cites:

Information Journal Paper

Title

DEPLETION OF SEROTONIN SYNTHESIS WITH P-CPA PRETREATMENT ALTERS EEG IN URETHANE ANESTHETIZED RATS UNDER WHOLE BODY HYPERTHERMIA

Author(s)

SINHA R.K. | AGGARWAL Y. | Issue Writer Certificate

Keywords

HYPERTHERMIA

URETHANE ANESTHESIA

PARA-CHLOROPHENYLALANINE (P-CPA)

ELECTROENCEPHALOGRAM (EEG)

BRAIN EDEMA

Abstract

Background: Serotonin is believed as an important factor in brain function. The role of serotonin in cerebral psycho-patho-physiology has already been well established. However, the function of serotonin antagonist in anesthetized subjects under HYPERTHERMIA has not been studied properly. Methods: Experiments were performed in three groups of urethane-anesthetized rats, such as: (i) control group, (ii) whole body HYPERTHERMIA group and (iii) p-CPA (para-Chlorophenylalanine) pretreated HYPERTHERMIA group. HYPERTHERMIA was produced by subjecting the rats to high ambient temperature of 38 ± 1ºC (relative humidity 45-50%). Each group was divided for EEG (electroencephalogram) study and for determination of edematous swelling in the brain. Results: Urethane anesthetized rats under HYPERTHERMIA show highly significant reduction in their survival time. The body temperature recorded during the HYPERTHERMIA was observed with significant and linear rise with marked increase in brain water content, which was analyzed just after the death of the subjects. The results of the electroencephalographic study in urethane-anesthetized rats recorded before death indicate that brain function varies in systematic manner during HYPERTHERMIA as sequential changes in EEG patterns were observed. However, a serotonin antagonist, p-CPA pretreatment increases the survival time with significant reduction in edematous swelling in brain but it does not affect the relationship between the core body temperature and the brain cortical potentials as observed in urethane anesthetized subjects exposed to whole body HYPERTHERMIA. The core body temperature in p-CPA pretreated rats show non-linear relationship with respect to the exposure time as it was observed in drug untreated subjects. Conclusion: The findings of the present study indicate that although pretreatment of p-CPA in rats has a marked correlation between the extravasations of the blood-brain barrier under HYPERTHERMIA but shows minimum effect on the EEG in a model of HYPERTHERMIA under irreversible anesthesia.

Cites

No record.

References

No record.

Cite

APA: Copy

SINHA, R.K., & AGGARWAL, Y.. (2007). DEPLETION OF SEROTONIN SYNTHESIS WITH P-CPA PRETREATMENT ALTERS EEG IN URETHANE ANESTHETIZED RATS UNDER WHOLE BODY HYPERTHERMIA. IRANIAN BIOMEDICAL JOURNAL, 11(1), 33-39. SID. https://sid.ir/paper/277133/en

Vancouver: Copy

SINHA R.K., AGGARWAL Y.. DEPLETION OF SEROTONIN SYNTHESIS WITH P-CPA PRETREATMENT ALTERS EEG IN URETHANE ANESTHETIZED RATS UNDER WHOLE BODY HYPERTHERMIA. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2007;11(1):33-39. Available from: https://sid.ir/paper/277133/en

IEEE: Copy

R.K. SINHA, and Y. AGGARWAL, “DEPLETION OF SEROTONIN SYNTHESIS WITH P-CPA PRETREATMENT ALTERS EEG IN URETHANE ANESTHETIZED RATS UNDER WHOLE BODY HYPERTHERMIA,” IRANIAN BIOMEDICAL JOURNAL, vol. 11, no. 1, pp. 33–39, 2007, [Online]. Available: https://sid.ir/paper/277133/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops