COMPARISON OF URINARY N-ACETYL-BETA-D-GLUCOSAMINIDASE IN NON-DIABETIC SUBJECTS AND TYPE2 DIABETIC PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SAFAEI JAZI E.; BEHESHTITABAR M.; AMINI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2011 | Volume:13 | Issue:3 (SN 57) Page(s): 243-248

Download Full-Text

Persian Verion

View:

1,011

Download:

Cites:

Information Journal Paper

Title

COMPARISON OF URINARY N-ACETYL-BETA-D-GLUCOSAMINIDASE IN NON-DIABETIC SUBJECTS AND TYPE2 DIABETIC PATIENTS

Author(s)

SAFAEI JAZI E. | BEHESHTITABAR M. | AMINI M. | Issue Writer Certificate

Keywords

TYPE2 DIABETESQ2

N-ACETYL-BETA-D-GLUCOSAMINIDASEQ2

DIABETIC NEPHROPATHYQ2

Abstract

Introduction: For renal impairment, in clinical diagnostic practice currently the assessment of urinary enzymes is used. One of these enzymes is N-ACETYL-BETA-D-GLUCOSAMINIDASE (NAG), a widely distributed lysosomal enzyme with a molecular weight of 140000 Da, located predominantly in the renal proximal tubules. NAG activity in the urine increases in patients with various glomerulonephritides, DIABETIC NEPHROPATHY, tubulointerstitial diseases, renal allograft rejection and toxic renal injury.Materials and Methods: The study population included 30 type 2 diabetes and 30 non-diabetic subjects, and the latter group had normal glucose tolerance test. Urinary NAG, albumin, creatinine, serum glucose and HbA1c% were measured. The urinary NAG and albumin index in non-diabetic subjects were compared with those of the diabetic patients. The differences between the two groups (HbA1c<%7 and HbA1c>%7) were calculated.Results: Significant differences were determined in NAG activity between the diabetic and non-diabetic subjects (p<0.001). Excreted urinary NAG increased in diabetes patients with poor glycemic control (HbA1c>7%) compared to those with good glycemic control (HbA1c<7%), an increase that was significant (p<0.05). There was an increase in urinary NAG excretion in diabetic patients with abnormal albumin excretion compared to those with normal albumin excretion (p= 0.001). NAG excretion had a positive correlation with blood glucose and HbA1c%.Conclusion: Our results showed that determination of urinary NAG activity could be useful marker of early renal damage in DIABETIC NEPHROPATHY and confirmed the use of NAG enzyme as a routine screening test.

Cites

No record.

References

No record.

Cite

APA: Copy

SAFAEI JAZI, E., BEHESHTITABAR, M., & AMINI, M.. (2011). COMPARISON OF URINARY N-ACETYL-BETA-D-GLUCOSAMINIDASE IN NON-DIABETIC SUBJECTS AND TYPE2 DIABETIC PATIENTS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 13(3 (SN 57)), 243-248. SID. https://sid.ir/paper/27728/en

Vancouver: Copy

SAFAEI JAZI E., BEHESHTITABAR M., AMINI M.. COMPARISON OF URINARY N-ACETYL-BETA-D-GLUCOSAMINIDASE IN NON-DIABETIC SUBJECTS AND TYPE2 DIABETIC PATIENTS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2011;13(3 (SN 57)):243-248. Available from: https://sid.ir/paper/27728/en

IEEE: Copy

E. SAFAEI JAZI, M. BEHESHTITABAR, and M. AMINI, “COMPARISON OF URINARY N-ACETYL-BETA-D-GLUCOSAMINIDASE IN NON-DIABETIC SUBJECTS AND TYPE2 DIABETIC PATIENTS,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 13, no. 3 (SN 57), pp. 243–248, 2011, [Online]. Available: https://sid.ir/paper/27728/en

Related Journal Papers