EFFECTS OF VALPROIC ACID, A HISTONE DEACETYLASE INHIBITOR, ON IMPROVEMENT OF LOCOMOTOR FUNCTION IN RAT SPINAL CORD INJURY BASED ON EPIGENETIC SCIENCE

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ABDANIPOUR ALIREZA; SCHLUESENER HERMANN J.; TIRAIHI TAKI

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Journal: Iranian Biomedical Journal Year:2012 | Volume:16 | Issue:2 Page(s): 90-100

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Information Journal Paper

Title

EFFECTS OF VALPROIC ACID, A HISTONE DEACETYLASE INHIBITOR, ON IMPROVEMENT OF LOCOMOTOR FUNCTION IN RAT SPINAL CORD INJURY BASED ON EPIGENETIC SCIENCE

Author(s)

ABDANIPOUR ALIREZA | SCHLUESENER HERMANN J. | TIRAIHI TAKI | Issue Writer Certificate

Keywords

INFLAMMATION

EPIGENETICS

VALPROIC ACID (VPA)

Abstract

Background: The primary phase of traumatic spinal cord injury (SCI) starts by a complex local inflammatory reaction such as secretion of pro-inflammatory cytokines from microglia and injured cells that substantially contribute to exacerbating pathogenic events in secondary phase. Valproic acid (VPA) is a histone deacetylase inhibitor. Acetylation of histones is critical to cellular inflammatory and repair processes.Methods: In this study, rats were randomly assigned to five experimental groups (laminectomy, untreated, and three VPA-treated groups). For SCI, severe contusion was used. In treated groups, VPA was administered intraperitoneally at doses of 100, 200 and 400 mg/kg daily three hours after injury for 7 days. To compare locomotor improvement among experimental groups, behavioral assessments were performed by the Basso, Beattie and Bresnahan (BBB) rating scale. The expression of neurotrophins was evaluated by RT-PCR and real-time PCR.Results: VPA administration increased regional brain-derived neurotrophic factor and glial cell-derived neurotrophic factor mRNA levels. Local INFLAMMATION and the expression of the lysosomal marker ED1 by activated macrophages/microglial cells were reduced by VPA and immunoreactivity of acetylated histone and microtubule-associated protein were increased.Conclusion: The results showed a reduction in the development of secondary damage in rat spinal cord trauma with an improvement in the open field test (BBB scale) with rapid recovery.

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APA: Copy

ABDANIPOUR, ALIREZA, SCHLUESENER, HERMANN J., & TIRAIHI, TAKI. (2012). EFFECTS OF VALPROIC ACID, A HISTONE DEACETYLASE INHIBITOR, ON IMPROVEMENT OF LOCOMOTOR FUNCTION IN RAT SPINAL CORD INJURY BASED ON EPIGENETIC SCIENCE. IRANIAN BIOMEDICAL JOURNAL, 16(2), 90-100. SID. https://sid.ir/paper/277328/en

Vancouver: Copy

ABDANIPOUR ALIREZA, SCHLUESENER HERMANN J., TIRAIHI TAKI. EFFECTS OF VALPROIC ACID, A HISTONE DEACETYLASE INHIBITOR, ON IMPROVEMENT OF LOCOMOTOR FUNCTION IN RAT SPINAL CORD INJURY BASED ON EPIGENETIC SCIENCE. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2012;16(2):90-100. Available from: https://sid.ir/paper/277328/en

IEEE: Copy

ALIREZA ABDANIPOUR, HERMANN J. SCHLUESENER, and TAKI TIRAIHI, “EFFECTS OF VALPROIC ACID, A HISTONE DEACETYLASE INHIBITOR, ON IMPROVEMENT OF LOCOMOTOR FUNCTION IN RAT SPINAL CORD INJURY BASED ON EPIGENETIC SCIENCE,” IRANIAN BIOMEDICAL JOURNAL, vol. 16, no. 2, pp. 90–100, 2012, [Online]. Available: https://sid.ir/paper/277328/en

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