MOLECULAR GENETIC ANALYSIS OF THE VARIABLE NUMBER OF TANDEM-REPEAT ALLELES AT THE PHENYLALANINE HYDROXYLASE GENE IN IRANIAN AZERI TURKISH POPULATION (SHORT COMMUNICATION)

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BAGHERI MORTEZA; ABDI RAD ISA; HOSSEINI JAZANI NIMA; ZARRIN RASOUL; GHAZAVI AHAD

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Journal: Iranian Biomedical Journal Year:2015 | Volume:19 | Issue:3 Page(s): 183-187

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Title

MOLECULAR GENETIC ANALYSIS OF THE VARIABLE NUMBER OF TANDEM-REPEAT ALLELES AT THE PHENYLALANINE HYDROXYLASE GENE IN IRANIAN AZERI TURKISH POPULATION (SHORT COMMUNICATION)

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Keywords

PHENYLALANINE HYDROXYLASE

POPULATION GENETICS

VARIABLE NUMBERS OF TANDEM-REPEAT

Abstract

Background: The VARIABLE NUMBERS OF TANDEM-REPEAT (VNTR) alleles at the PHENYLALANINE HYDROXYLASE (PAH) gene have been used in carrier detection and prenatal diagnosis in phenylketonuria families. This study was carried out to analyze VNTR alleles at thePAH gene in Iranian Azeri Turkish population.Methods: In this study, 200 alleles from general population were studied by PCR.Results: The frequencies of VNTR alleles were 45%, 46%, 2%, 3%, 1%, and 3% in studied group regarding 3, 8, 9, 11, 12, and 13 repeat copies, respectively. Statistically significant differences were not found between expected and observed frequencies of VNTR genotypes (P>0.05).Conclusions: VNTR alleles with three and eight repeats were frequent, and the VNTR alleles with 13 repeats showed 3% frequency in the tested group. This study is the first report on tested population genetic structure using VNTR alleles at thePAH gene.

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APA: Copy

BAGHERI, MORTEZA, ABDI RAD, ISA, HOSSEINI JAZANI, NIMA, ZARRIN, RASOUL, & GHAZAVI, AHAD. (2015). MOLECULAR GENETIC ANALYSIS OF THE VARIABLE NUMBER OF TANDEM-REPEAT ALLELES AT THE PHENYLALANINE HYDROXYLASE GENE IN IRANIAN AZERI TURKISH POPULATION (SHORT COMMUNICATION). IRANIAN BIOMEDICAL JOURNAL, 19(3), 183-187. SID. https://sid.ir/paper/277332/en

Vancouver: Copy

BAGHERI MORTEZA, ABDI RAD ISA, HOSSEINI JAZANI NIMA, ZARRIN RASOUL, GHAZAVI AHAD. MOLECULAR GENETIC ANALYSIS OF THE VARIABLE NUMBER OF TANDEM-REPEAT ALLELES AT THE PHENYLALANINE HYDROXYLASE GENE IN IRANIAN AZERI TURKISH POPULATION (SHORT COMMUNICATION). IRANIAN BIOMEDICAL JOURNAL[Internet]. 2015;19(3):183-187. Available from: https://sid.ir/paper/277332/en

IEEE: Copy

MORTEZA BAGHERI, ISA ABDI RAD, NIMA HOSSEINI JAZANI, RASOUL ZARRIN, and AHAD GHAZAVI, “MOLECULAR GENETIC ANALYSIS OF THE VARIABLE NUMBER OF TANDEM-REPEAT ALLELES AT THE PHENYLALANINE HYDROXYLASE GENE IN IRANIAN AZERI TURKISH POPULATION (SHORT COMMUNICATION),” IRANIAN BIOMEDICAL JOURNAL, vol. 19, no. 3, pp. 183–187, 2015, [Online]. Available: https://sid.ir/paper/277332/en

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