ASSOCIATION OF LECITHIN CHOLESTEROL ACYLTRANSFERASE RS5923 POLYMORPHISM IN IRANIAN INDIVIDUALS WITH EXTREMELY LOW HIGH-DENSITY LIPOPROTEIN CHOLESTEROL: TEHRAN LIPID AND GLUCOSE STUDY

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NASERI MOHSEN; HEDAYATI MEHDI; DANESHPOUR MARYAM SADAT; BANDARIAN FATEMEH; AZIZI FEREIDOUN

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Journal: Iranian Biomedical Journal Year:2015 | Volume:19 | Issue:3 Page(s): 172-176

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Title

ASSOCIATION OF LECITHIN CHOLESTEROL ACYLTRANSFERASE RS5923 POLYMORPHISM IN IRANIAN INDIVIDUALS WITH EXTREMELY LOW HIGH-DENSITY LIPOPROTEIN CHOLESTEROL: TEHRAN LIPID AND GLUCOSE STUDY

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Keywords

POLYMORPHISM

SINGLE NUCLEOTIDE

LIPOPROTEINS

Abstract

Background: The serum concentration of high-density lipoprotein cholesterol (HDL-C) is one of the important heritable risk factors for cardiovascular disease and is a target for therapeutic intervention. In this study, we aimed to evaluate the effects of lecithin cholesterol acyltransferase (LCAT) gene POLYMORPHISM rs5923 on LCAT enzyme activity and serum HDL-C concentration.Methods: The study population was selected from consecutive individuals with HDL-C£ 5th percentile (n=73) and extremely high HDL-C ³ 95th percentile (n=57) who had participated in the Tehran Lipid and Glucose Study. The rs5923 POLYMORPHISM was genotyped using direct sequencing. LCAT activity was measured by fluorometric assay kit, and lipid concentrations were measured using the enzymatic colorimetric method.Results: The genotype frequencies were significantly different between the high HDL-C group (CC 94.7%, CT 5.3%) and the low HDL-C group (CC 83.6%, CT 16.4%) (P=0.048). The Tallele frequencies in subjects with low and high HDL-C were 0.082 and 0.026, respectively (P=0.16). The association of the single-nucleotide POLYMORPHISM rs5923 with low HDL-C was not statistically significant after adjustment for age, sex, and BMI (odd ratio=2.65, 95% confidence interval=0.32-21.5, P=0.36, regression logistic analysis). Also, the effects of LCAT enzyme activity did not depend on the HDL-C level (P=0.24).Conclusion: rs5923 POLYMORPHISM is not associated with low HDL-C levels in Iranian population.

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APA: Copy

NASERI, MOHSEN, HEDAYATI, MEHDI, DANESHPOUR, MARYAM SADAT, BANDARIAN, FATEMEH, & AZIZI, FEREIDOUN. (2015). ASSOCIATION OF LECITHIN CHOLESTEROL ACYLTRANSFERASE RS5923 POLYMORPHISM IN IRANIAN INDIVIDUALS WITH EXTREMELY LOW HIGH-DENSITY LIPOPROTEIN CHOLESTEROL: TEHRAN LIPID AND GLUCOSE STUDY. IRANIAN BIOMEDICAL JOURNAL, 19(3), 172-176. SID. https://sid.ir/paper/277337/en

Vancouver: Copy

NASERI MOHSEN, HEDAYATI MEHDI, DANESHPOUR MARYAM SADAT, BANDARIAN FATEMEH, AZIZI FEREIDOUN. ASSOCIATION OF LECITHIN CHOLESTEROL ACYLTRANSFERASE RS5923 POLYMORPHISM IN IRANIAN INDIVIDUALS WITH EXTREMELY LOW HIGH-DENSITY LIPOPROTEIN CHOLESTEROL: TEHRAN LIPID AND GLUCOSE STUDY. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2015;19(3):172-176. Available from: https://sid.ir/paper/277337/en

IEEE: Copy

MOHSEN NASERI, MEHDI HEDAYATI, MARYAM SADAT DANESHPOUR, FATEMEH BANDARIAN, and FEREIDOUN AZIZI, “ASSOCIATION OF LECITHIN CHOLESTEROL ACYLTRANSFERASE RS5923 POLYMORPHISM IN IRANIAN INDIVIDUALS WITH EXTREMELY LOW HIGH-DENSITY LIPOPROTEIN CHOLESTEROL: TEHRAN LIPID AND GLUCOSE STUDY,” IRANIAN BIOMEDICAL JOURNAL, vol. 19, no. 3, pp. 172–176, 2015, [Online]. Available: https://sid.ir/paper/277337/en

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