AGE-SPECIFIC GASTRIC CANCER RISK INDICATED BY THE COMBINATION OF HELICOBACTER PYLORI SERO-STATUS AND SERUM PEPSINOGEN LEVELS

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EYBPOOSH SANA; TALEBKHAN YEGANEH; SABERI SAMANEH; ESMAEILI MARYAM; OGHALAIE AKBAR; EBRAHIMZADEH FATEMEH; KARIMI TOKTAM; ABDIRAD AFSHIN; NAHVIJOU AZIN; MOHAGHEGHI MOHAMMAD ALI; ESHAGH HOSSEINI MAHMOUD; MOHAMMADI MARJAN

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Journal: Iranian Biomedical Journal Year:2015 | Volume:19 | Issue:3 Page(s): 133-142

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Title

AGE-SPECIFIC GASTRIC CANCER RISK INDICATED BY THE COMBINATION OF HELICOBACTER PYLORI SERO-STATUS AND SERUM PEPSINOGEN LEVELS

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BIOMARKERS

DEMOGRAPHY

AGE DISTRIBUTION

Abstract

Background: Serologic screening of gastric cancer (GC) by serum pepsinogens (sPG) levels and Helicobacter pylori (Hp) sero-status, though highly informative, has provided heterogeneous results. Here, we have evaluated the modifying effects of demographic factors on the risk impact of Hp sero-status/sPG levels in gastric cancer, with particular emphasis on age.Methods: A cross-sectional study was carried out on 1341 individuals (GC=578, healthy=763), who were stratified into two age groups: 35-59 years (middle-aged, n=830) and³ 60 years (60 years-plus, n=511). Demographic factors and serological states (Hp sero-staus and sPG levels) were recorded by subject interview and serum ELISAs, respectively. Covariate-specific odds ratios were calculated by multivariable logistic regression.Results: Hp infection was consistently associated with increased sPGI and sPGII levels in the 60 year-plus, but not the middle-aged group. The joint examination of the variable states of the three serum BIOMARKERS (Hp serology, sPGI, and sPGI/II ratio), in the 60 year-plus age group, demonstrated a stepwise escalation of risk from the single (sPGIlow; OR=2.6), to double (sPGI low /sPGI/II low; OR=3.55, and Hppositive /sPGI low; OR=5.0) and ultimately triple (Hp positive /PGI low /PGI/II low; OR=10.48) positive states, in reference to the triple negatives. However, this pattern was not exhibited in the middle-aged subjects.Conclusion: Age was clearly identified as a modifying factor on the risk projection of the combined states of Hp serology and sPG levels in gastric cancer screening, reflected by the augmented (~10.5 fold) risk of GC in the triple positive (Hppositive /sPGI low /sPGI/II low) 60 year-plus subjects, which was not evident in the middle-aged group.

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APA: Copy

EYBPOOSH, SANA, TALEBKHAN, YEGANEH, SABERI, SAMANEH, ESMAEILI, MARYAM, OGHALAIE, AKBAR, EBRAHIMZADEH, FATEMEH, KARIMI, TOKTAM, ABDIRAD, AFSHIN, NAHVIJOU, AZIN, MOHAGHEGHI, MOHAMMAD ALI, ESHAGH HOSSEINI, MAHMOUD, & MOHAMMADI, MARJAN. (2015). AGE-SPECIFIC GASTRIC CANCER RISK INDICATED BY THE COMBINATION OF HELICOBACTER PYLORI SERO-STATUS AND SERUM PEPSINOGEN LEVELS. IRANIAN BIOMEDICAL JOURNAL, 19(3), 133-142. SID. https://sid.ir/paper/277340/en

Vancouver: Copy

EYBPOOSH SANA, TALEBKHAN YEGANEH, SABERI SAMANEH, ESMAEILI MARYAM, OGHALAIE AKBAR, EBRAHIMZADEH FATEMEH, KARIMI TOKTAM, ABDIRAD AFSHIN, NAHVIJOU AZIN, MOHAGHEGHI MOHAMMAD ALI, ESHAGH HOSSEINI MAHMOUD, MOHAMMADI MARJAN. AGE-SPECIFIC GASTRIC CANCER RISK INDICATED BY THE COMBINATION OF HELICOBACTER PYLORI SERO-STATUS AND SERUM PEPSINOGEN LEVELS. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2015;19(3):133-142. Available from: https://sid.ir/paper/277340/en

IEEE: Copy

SANA EYBPOOSH, YEGANEH TALEBKHAN, SAMANEH SABERI, MARYAM ESMAEILI, AKBAR OGHALAIE, FATEMEH EBRAHIMZADEH, TOKTAM KARIMI, AFSHIN ABDIRAD, AZIN NAHVIJOU, MOHAMMAD ALI MOHAGHEGHI, MAHMOUD ESHAGH HOSSEINI, and MARJAN MOHAMMADI, “AGE-SPECIFIC GASTRIC CANCER RISK INDICATED BY THE COMBINATION OF HELICOBACTER PYLORI SERO-STATUS AND SERUM PEPSINOGEN LEVELS,” IRANIAN BIOMEDICAL JOURNAL, vol. 19, no. 3, pp. 133–142, 2015, [Online]. Available: https://sid.ir/paper/277340/en

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