مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

IS BAX/BCL-2 RATIO CONSIDERED AS A PROGNOSTIC MARKER WITH AGE AND TUMOR LOCATION IN COLORECTAL CANCER?

Pages

  69-75

Abstract

 Background: Bax and Bcl-2 are the major members of Bcl-2 family whose play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial dysfunction. Therefore, the balance between pro- and anti-apoptotic members of this family can determine the cellular fate.Methods: In this study, the relative level of mRNA expression of Bax and Bcl-2 genes was determined using RNA extraction, cDNA synthesis and RT-qPCR technique from 22 tumoral tissues and adjacent non-tumoral tissues from adenocarcinoma COLORECTAL CANCER.Results: The potential prognostic and predictive significance of Bax and Bcl-2 gene expression and BAX/BCL-2 RATIO were demonstrated in COLORECTAL CANCER. The significant correlation between qPCR data and different clinicopathologic parameters of colorectal carcinoma, including age, gender, tumor size, tumor stage, tumor location, and tumor differentiation was also examined. Interestingly, no significant correlation was seen between Bax and BCL-2 EXPRESSIONs and clinicopathological parameters of COLORECTAL CANCER. However, BAX/BCL-2 RATIO was statistically correlated with age and tumor location. Patients with age above 50 showed decreased levels of BAX/BCL-2 RATIO. Moreover, the BAX/BCL-2 RATIO was significantly lower in tumors resected from colon compared to sigmoid colon, rectosigmoid and rectum tumors.Conclusion: This study indicates a significant correlation between age and tumor location with Bax/Bcl-2 expression ratio, suggesting predictive value as a potential molecular marker of COLORECTAL CANCER.

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    APA: Copy

    KHODAPASAND, EHSAN, JAFARZADEH, NARGES, FARROKHI, FARID, KAMALIDEHGHAN, BEHNAM, & HOUSHMAND, MASSOUD. (2015). IS BAX/BCL-2 RATIO CONSIDERED AS A PROGNOSTIC MARKER WITH AGE AND TUMOR LOCATION IN COLORECTAL CANCER?. IRANIAN BIOMEDICAL JOURNAL, 19(2), 69-75. SID. https://sid.ir/paper/277343/en

    Vancouver: Copy

    KHODAPASAND EHSAN, JAFARZADEH NARGES, FARROKHI FARID, KAMALIDEHGHAN BEHNAM, HOUSHMAND MASSOUD. IS BAX/BCL-2 RATIO CONSIDERED AS A PROGNOSTIC MARKER WITH AGE AND TUMOR LOCATION IN COLORECTAL CANCER?. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2015;19(2):69-75. Available from: https://sid.ir/paper/277343/en

    IEEE: Copy

    EHSAN KHODAPASAND, NARGES JAFARZADEH, FARID FARROKHI, BEHNAM KAMALIDEHGHAN, and MASSOUD HOUSHMAND, “IS BAX/BCL-2 RATIO CONSIDERED AS A PROGNOSTIC MARKER WITH AGE AND TUMOR LOCATION IN COLORECTAL CANCER?,” IRANIAN BIOMEDICAL JOURNAL, vol. 19, no. 2, pp. 69–75, 2015, [Online]. Available: https://sid.ir/paper/277343/en

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